UGA2 succinate-semialdehyde dehydrogenase (NAD(P)(+)) [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: UGA2
Official Full Name: succinate-semialdehyde dehydrogenase (NAD(P)(+))
Primary source: SGD:S000000210
Locus tag: YBR006W
See related: AllianceGenome:SGD:S000000210; FungiDB:YBR006W; VEuPathDB:YBR006W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: UGA5
Summary: Enables succinate-semialdehyde dehydrogenase [NAD(P)+] activity. Involved in cellular response to oxidative stress; gamma-aminobutyrate shunt; and gamma-aminobutyric acid catabolic process. Located in cytoplasm. Human ortholog(s) of this gene implicated in succinic semialdehyde dehydrogenase deficiency. Orthologous to human ALDH5A1 (aldehyde dehydrogenase 5 family member A1). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs: all
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Chromosome II - NC_001134.8 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

GAD1, UGA1 and UGA2 mediates thermotolerance by reducing reactive oxygen production.
Title: GABA shunt mediates thermotolerance in Saccharomyces cerevisiae by reducing reactive oxygen production.
UGA1 and UGA2, are subject to amino acid regulation as it occurs for UGA4.
Title: Common features and differences in the expression of the three genes forming the UGA regulon in Saccharomyces cerevisiae.

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	IEA Inferred from Electronic Annotation more info
enables succinate-semialdehyde dehydrogenase (NAD+) activity	IBA Inferred from Biological aspect of Ancestor more info
enables succinate-semialdehyde dehydrogenase (NAD+) activity	IEA Inferred from Electronic Annotation more info
enables succinate-semialdehyde dehydrogenase (NADP+) activity	IEA Inferred from Electronic Annotation more info
enables succinate-semialdehyde dehydrogenase [NAD(P)+] activity	IEA Inferred from Electronic Annotation more info
enables succinate-semialdehyde dehydrogenase [NAD(P)+] activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular response to oxidative stress	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in gamma-aminobutyrate shunt	IGI Inferred from Genetic Interaction more info	PubMed
involved_in gamma-aminobutyrate shunt	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in gamma-aminobutyric acid catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in gamma-aminobutyric acid catabolic process	IEA Inferred from Electronic Annotation more info
involved_in gamma-aminobutyric acid catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

NP_009560.1

Succinate semialdehyde dehydrogenase; involved in the utilization of gamma-aminobutyrate (GABA) as a nitrogen source; part of the 4-aminobutyrate and glutamate degradation pathways; localized to the cytoplasm