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FMT1 methionyl-tRNA formyltransferase [ Saccharomyces cerevisiae S288C ]

Gene ID: 852270, updated on 18-Jan-2023

Summary

Gene symbol
FMT1
Gene description
methionyl-tRNA formyltransferase
Primary source
SGD:S000000109
Locus tag
YBL013W
See related
AllianceGenome:SGD:S000000109
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables methionyl-tRNA formyltransferase activity. Involved in conversion of methionyl-tRNA to N-formyl-methionyl-tRNA. Located in mitochondrion. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 15 and nuclear type mitochondrial complex I deficiency 27. Orthologous to human MTFMT (mitochondrial methionyl-tRNA formyltransferase). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

See FMT1 in Genome Data Viewer
Location:
chromosome: II
Exon count:
1
Sequence:
Chromosome: II; NC_001134.8 (202056..203261)

Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene tRNA-Gly Neighboring gene Rrn6p Neighboring gene bifunctional glycerol-3-phosphate/glycerone-phosphate O-acyltransferase SCT1 Neighboring gene Laa2p

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GO

Function Evidence Code Pubs
enables methionyl-tRNA formyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables methionyl-tRNA formyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables methionyl-tRNA formyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables methionyl-tRNA formyltransferase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrial matrix IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
methionyl-tRNA formyltransferase
NP_009540.2
  • Methionyl-tRNA formyltransferase; catalyzes formylation of mitochondria initiator Met-tRNA and residual cytosolic Met-tRNA due to inefficient translocation into the mitochondrial matrix; starvation or stationary phase entry increases Gcn2p phosphorylation-mediated cytosolic retention of Fmt1p, enhancing N-terminal protein formylation and ultimately N-end rule pathway mediated destruction that involves the Psh1p ubiquitin ligase; potential Cdc28p substrate

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001134.8 Reference assembly

    Range
    202056..203261
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178253.1NP_009540.2  TPA: methionyl-tRNA formyltransferase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009540.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P32785, Q6RUA6
    UniProtKB/TrEMBL
    N1P909
    Conserved Domains (1) summary
    TIGR00460
    Location:30393
    fmt; methionyl-tRNA formyltransferase