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FUS3 mitogen-activated serine/threonine-protein kinase FUS3 [ Saccharomyces cerevisiae S288C ]

Gene ID: 852265, updated on 18-Jan-2023

Summary

Gene symbol
FUS3
Gene description
mitogen-activated serine/threonine-protein kinase FUS3
Primary source
SGD:S000000112
Locus tag
YBL016W
See related
AllianceGenome:SGD:S000000112
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
DAC2
Summary
Enables MAP kinase activity. Involved in several processes, including invasive growth in response to glucose limitation; negative regulation of transposition, RNA-mediated; and pheromone response MAPK cascade. Located in cytoplasm; mating projection tip; and nucleus. Human ortholog(s) of this gene implicated in Noonan syndrome 13; carcinoma (multiple); and pulmonary hypertension. Orthologous to several human genes including MAPK1 (mitogen-activated protein kinase 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

See FUS3 in Genome Data Viewer
Location:
chromosome: II
Exon count:
1
Sequence:
Chromosome: II; NC_001134.8 (192451..193512)

Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene ribonuclease P Neighboring gene type I sorting receptor Neighboring gene acetyl-CoA hydrolase Neighboring gene tRNA-Ile

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

  • Homologs of the FUS3 gene: The FUS3 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, mouse, rat, zebrafish, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, A.thaliana, and rice.
  • Orthologs

Gene Ontology Provided by GO

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables MAP kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables MAP kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein kinase activity HDA PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasmic stress granule HDA PubMed 
located_in mating projection tip IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
located_in periplasmic space IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
mitogen-activated serine/threonine-protein kinase FUS3
NP_009537.1
  • Mitogen-activated serine/threonine protein kinase involved in mating; phosphoactivated by Ste7p; substrates include Ste12p, Far1p, Bni1p, Sst2p; inhibits invasive growth during mating by phosphorylating Tec1p, promoting its; inhibits recruitment of Ste5p, Cdc42p-mediated asymmetry and mating morphogenesis

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001134.8 Reference assembly

    Range
    192451..193512
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178256.1NP_009537.1  TPA: mitogen-activated serine/threonine-protein kinase FUS3 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009537.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VPY4, P16892
    UniProtKB/TrEMBL
    A0A6C1DMX2, A6ZKT2, G2W8Z3, N1P8T7