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MCM2 MCM DNA helicase complex subunit MCM2 [ Saccharomyces cerevisiae S288C ]

Gene ID: 852258, updated on 15-May-2020

Summary

Gene symbol
MCM2
Gene description
MCM DNA helicase complex subunit MCM2
Primary source
SGD:S000000119
Locus tag
YBL023C
Gene type
protein coding
RNA name
MCM DNA helicase complex subunit MCM2
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces

Genomic context

See MCM2 in Genome Data Viewer
Location:
chromosome: II
Exon count:
1
Sequence:
Chromosome: II; NC_001134.8 (174920..177526, complement)

Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene Rrn10p Neighboring gene tRNA (cytosine-C5-)-methyltransferase Neighboring gene ATP-dependent Lon protease PIM1 Neighboring gene Hap3p

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

  • Homologs of the MCM2 gene: The MCM2 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, A.thaliana, rice, and frog.

Gene Ontology Provided by GO

Function Evidence Code Pubs
contributes_to 3'-5' DNA helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ATP binding IEA
Inferred from Electronic Annotation
more info
 
DNA binding IEA
Inferred from Electronic Annotation
more info
 
DNA helicase activity IEA
Inferred from Electronic Annotation
more info
 
DNA replication origin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA replication origin binding IDA
Inferred from Direct Assay
more info
PubMed 
chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
helicase activity IEA
Inferred from Electronic Annotation
more info
 
hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
single-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
contributes_to single-stranded DNA binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
contributes_to single-stranded DNA-dependent ATP-dependent DNA helicase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
DNA replication IEA
Inferred from Electronic Annotation
more info
 
DNA replication initiation IEA
Inferred from Electronic Annotation
more info
 
DNA strand elongation involved in DNA replication IMP
Inferred from Mutant Phenotype
more info
PubMed 
DNA unwinding involved in DNA replication IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell cycle IEA
Inferred from Electronic Annotation
more info
 
cellular response to DNA damage stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
double-strand break repair via break-induced replication IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
double-strand break repair via break-induced replication IMP
Inferred from Mutant Phenotype
more info
PubMed 
mitotic DNA replication initiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitotic DNA replication initiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of DNA helicase activity IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of DNA helicase activity IEA
Inferred from Electronic Annotation
more info
 
pre-replicative complex assembly involved in nuclear cell cycle DNA replication IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
pre-replicative complex assembly involved in nuclear cell cycle DNA replication IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
CMG complex IDA
Inferred from Direct Assay
more info
PubMed 
DNA replication preinitiation complex IDA
Inferred from Direct Assay
more info
PubMed 
MCM complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
MCM complex IDA
Inferred from Direct Assay
more info
PubMed 
MCM complex IEA
Inferred from Electronic Annotation
more info
 
cytoplasm HDA PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
nuclear pre-replicative complex IDA
Inferred from Direct Assay
more info
PubMed 
nucleus HDA PubMed 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IEA
Inferred from Electronic Annotation
more info
 
replication fork protection complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
MCM DNA helicase complex subunit MCM2
NP_009530.1
  • Protein involved in DNA replication; component of the Mcm2-7 hexameric helicase complex that binds chromatin as a part of the pre-replicative complex; relative distribution to the nucleus increases upon DNA replication stress

NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001134.8 Reference assembly

    Range
    174920..177526 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178263.1NP_009530.1  TPA: MCM DNA helicase complex subunit MCM2 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009530.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P29469
    Conserved Domains (3) summary
    smart00350
    Location:302846
    MCM; minichromosome maintenance proteins
    pfam12619
    Location:56193
    MCM2_N; Mini-chromosome maintenance protein 2
    pfam14551
    Location:212299
    MCM_N; MCM N-terminal domain
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