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PRX1 thioredoxin peroxidase PRX1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 852215, updated on 5-Aug-2018

Summary

Gene symbol
PRX1
Gene description
thioredoxin peroxidase PRX1
Primary source
SGD:S000000160
Locus tag
YBL064C
Gene type
protein coding
RNA name
thioredoxin peroxidase PRX1
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces

Genomic context

See PRX1 in Genome Data Viewer
Location:
chromosome: II
Exon count:
1
Sequence:
Chromosome: II; NC_001134.8 (100371..101156, complement)

Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene ubiquitin-specific protease UBP13 Neighboring gene Sef1p Neighboring gene Kip1p Neighboring gene Skt5p

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

  • Homologs of the PRX1 gene: The PRX1 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.cerevisiae, K.lactis, E.gossypii, M.oryzae, N.crassa, A.thaliana, rice, and frog.

Gene Ontology Provided by GO

Function Evidence Code Pubs
antioxidant activity IEA
Inferred from Electronic Annotation
more info
 
oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
peroxidase activity IEA
Inferred from Electronic Annotation
more info
 
peroxiredoxin activity IEA
Inferred from Electronic Annotation
more info
 
thioredoxin peroxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
thioredoxin peroxidase activity IDA
Inferred from Direct Assay
more info
PubMed 
thioredoxin peroxidase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
thioredoxin peroxidase activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Process Evidence Code Pubs
cell redox homeostasis IDA
Inferred from Direct Assay
more info
PubMed 
cell redox homeostasis IEA
Inferred from Electronic Annotation
more info
 
cell redox homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular oxidant detoxification IEA
Inferred from Electronic Annotation
more info
 
cellular response to oxidative stress IGI
Inferred from Genetic Interaction
more info
PubMed 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
response to cadmium ion IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
mitochondrion HDA PubMed 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion IEA
Inferred from Electronic Annotation
more info
 
mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 

General protein information

Preferred Names
thioredoxin peroxidase PRX1
NP_009489.1
  • Mitochondrial peroxiredoxin with thioredoxin peroxidase activity; has a role in reduction of hydroperoxides; reactivation requires Trr2p and glutathione; induced during respiratory growth and oxidative stress; phosphorylated; protein abundance increases in response to DNA replication stress

NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001134.8 Reference assembly

    Range
    100371..101156 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178304.1NP_009489.1  TPA: thioredoxin peroxidase PRX1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009489.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P34227
    Conserved Domains (1) summary
    cd03016
    Location:51259
    PRX_1cys; Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by ...
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