AAR2 U5 snRNP complex subunit AAR2 [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: AAR2
Official Full Name: U5 snRNP complex subunit AAR2
Primary source: SGD:S000000170
Locus tag: YBL074C
See related: AllianceGenome:SGD:S000000170; FungiDB:YBL074C; VEuPathDB:YBL074C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Involved in spliceosomal tri-snRNP complex assembly. Part of U5 snRNP. Orthologous to human AAR2 (AAR2 splicing factor). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs: all
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Chromosome II - NC_001134.8 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

Aar2p regulates both protein and RNA binding to Prp8p during U5 snRNP assembly
Title: Structural basis for dual roles of Aar2p in U5 snRNP assembly.
Prp8 interaction sites with Aar2 protein
Title: Prp8p dissection reveals domain structure and protein interaction sites.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in RNA splicing	IEA Inferred from Electronic Annotation more info
involved_in mRNA processing	IEA Inferred from Electronic Annotation more info
involved_in spliceosomal snRNP assembly	NAS Non-traceable Author Statement more info	PubMed
involved_in spliceosomal tri-snRNP complex assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in spliceosomal tri-snRNP complex assembly	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of U5 snRNP	IDA Inferred from Direct Assay more info	PubMed
part_of U5 snRNP	IPI Inferred from Physical Interaction more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	NAS Non-traceable Author Statement more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

NP_009479.1

Component of the U5 snRNP complex; required for splicing of U3 precursors; originally described as a splicing factor specifically required for splicing pre-mRNA of the MATa1 cistron

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The following sections contain reference sequences that belong to a specific genome build. Explain