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ROX3 Rox3p [ Saccharomyces cerevisiae S288C ]

Gene ID: 852184, updated on 23-Jul-2026
Official Symbol
ROX3
Official Full Name
Rox3p
Primary source
SGD:S000000189
Locus tag
YBL093C
See related
AllianceGenome:SGD:S000000189; FungiDB:YBL093C; VEuPathDB:YBL093C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
MED19; NUT3; RMR1; SSN7; SSX2
Summary
Enables transcription coactivator activity. Involved in regulation of transcription by RNA polymerase II and transcription initiation at RNA polymerase II promoter. Located in nucleus. Part of core mediator complex. [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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See ROX3 in Genome Data Viewer
Location:
chromosome: II
Exon count:
1
Sequence:
Chromosome: II; NC_001134.8 (44256..44918, complement)

Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene condensin subunit BRN1 Neighboring gene Mrx3p Neighboring gene 60S ribosomal protein eL32 RPL32 Neighboring gene phospholipid metabolism-regulating protein SCS22

Genomic Sequence:
NC_001134.8

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. The ROX3 gene encodes an essential nuclear protein involved in CYC7 gene expression in Saccharomyces cerevisiae. Rosenblum-Vos LS, et al. Mol Cell Biol, 1991 Nov. PMID 1656237, Free PMC Article
  2. Simultaneous recruitment of coactivators by Gcn4p stimulates multiple steps of transcription in vivo. Govind CK, et al. Mol Cell Biol, 2005 Jul. PMID 15964818, Free PMC Article
  3. Rox3 and Rts1 function in the global stress response pathway in baker's yeast. Evangelista CC Jr, et al. Genetics, 1996 Apr. PMID 8846889, Free PMC Article
  4. Regulation of hypoxic gene expression in yeast. Zitomer RS, et al. Kidney Int, 1997 Feb. PMID 9027731
  5. Regulation of nuclear genes encoding mitochondrial proteins in Saccharomyces cerevisiae. Brown TA, et al. J Bacteriol, 1995 Dec. PMID 7592476, Free PMC Article

See all (87) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables transcription coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription coactivator activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables transcription coregulator activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in RNA polymerase II preinitiation complex assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in RNA polymerase II preinitiation complex assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription elongation by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of transcription initiation by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of transcription initiation by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
involved_in transcription initiation at RNA polymerase II promoter IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transcription open complex formation at RNA polymerase II promoter IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of core mediator complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of core mediator complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of core mediator complex IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of mediator complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of mediator complex IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
Rox3p
NP_009459.1
  • Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001134.8 Reference assembly

    Range
    44256..44918 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178333.1 → NP_009459.1  Rox3p

    See identical proteins and their annotated locations for NP_009459.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VPR0, P25046
    UniProtKB/TrEMBL
    B3LNM5
    Conserved Domains (1) summary
    pfam08633
    Location:26 → 219
    Rox3; Rox3 mediator complex subunit
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P25046.3

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