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ATP1 F1F0 ATP synthase subunit alpha [ Saccharomyces cerevisiae S288C ]

Gene ID: 852177, updated on 24-Apr-2022

Summary

Gene symbol
ATP1
Gene description
F1F0 ATP synthase subunit alpha
Primary source
SGD:S000000195
Locus tag
YBL099W
See related
AllianceGenome:SGD:S000000195
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Contributes to ATP hydrolysis activity and proton-transporting ATP synthase activity, rotational mechanism. Involved in ATP synthesis coupled proton transport. Located in mitochondrial nucleoid. Part of mitochondrial proton-transporting ATP synthase, catalytic core. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 22 and mitochondrial complex V (ATP synthase) deficiency nuclear type 4. Orthologous to human ATP5F1A (ATP synthase F1 subunit alpha). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

See ATP1 in Genome Data Viewer
Location:
chromosome: II
Exon count:
1
Sequence:
Chromosome: II; NC_001134.8 (37053..38690)

Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene gag protein Neighboring gene gag-pol fusion protein Neighboring gene tRNA-Phe Neighboring gene kynurenine 3-monooxygenase Neighboring gene condensin subunit BRN1

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

  • Homologs of the ATP1 gene: The ATP1 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, A.thaliana, and frog.

Gene Ontology Provided by GO

Function Evidence Code Pubs
enables ADP binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ATP binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
contributes_to ATP hydrolysis activity IDA
Inferred from Direct Assay
more info
PubMed 
enables adenyl ribonucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
contributes_to proton-transporting ATP synthase activity, rotational mechanism IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
contributes_to proton-transporting ATP synthase activity, rotational mechanism IDA
Inferred from Direct Assay
more info
PubMed 
enables proton-transporting ATP synthase activity, rotational mechanism IEA
Inferred from Electronic Annotation
more info
 
contributes_to proton-transporting ATP synthase activity, rotational mechanism IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
involved_in ATP biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in ATP metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in proton motive force-driven ATP synthesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in proton motive force-driven ATP synthesis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in proton motive force-driven ATP synthesis IEA
Inferred from Electronic Annotation
more info
 
involved_in proton motive force-driven ATP synthesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in proton transmembrane transport IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
F1F0 ATP synthase subunit alpha
NP_009453.2
  • Alpha subunit of the F1 sector of mitochondrial F1F0 ATP synthase; which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; F1 translationally regulates ATP6 and ATP8 expression to achieve a balanced output of ATP synthase genes encoded in nucleus and mitochondria; phosphorylated; N-terminally propionylated in vivo

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001134.8 Reference assembly

    Range
    37053..38690
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178339.2NP_009453.2  TPA: F1F0 ATP synthase subunit alpha [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009453.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P07251
    Conserved Domains (1) summary
    PRK09281
    Location:42545
    PRK09281; F0F1 ATP synthase subunit alpha; Validated