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SFT2 Sft2p [ Saccharomyces cerevisiae S288C ]

Gene ID: 852172, updated on 10-Feb-2026
Official Symbol
SFT2
Official Full Name
Sft2p
Primary source
SGD:S000000198
Locus tag
YBL102W
See related
AllianceGenome:SGD:S000000198; FungiDB:YBL102W; VEuPathDB:YBL102W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Involved in retrograde transport, endosome to Golgi. Located in Golgi membrane and Golgi trans cisterna. Orthologous to human SFT2D3 (SFT2 domain containing 3). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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See SFT2 in Genome Data Viewer
Location:
chromosome: II
Exon count:
1
Sequence:
Chromosome: II; NC_001134.8 (24098..24745)

Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene Sea4p Neighboring gene Rtg3p Neighboring gene Ecm21p Neighboring gene uncharacterized protein

Genomic Sequence:
NC_001134.8

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. A SNARE-like protein required for traffic through the Golgi complex. Banfield DK, et al. Nature, 1995 Jun 29. PMID 7596416
  2. The dynamics of golgi protein traffic visualized in living yeast cells. Wooding S, et al. Mol Biol Cell, 1998 Sep. PMID 9725919, Free PMC Article
  3. Role for Gcs1p in regulation of Arl1p at trans-Golgi compartments. Liu YW, et al. Mol Biol Cell, 2005 Sep. PMID 15975906, Free PMC Article
  4. Got1p and Sft2p: membrane proteins involved in traffic to the Golgi complex. Conchon S, et al. EMBO J, 1999 Jul 15. PMID 10406798, Free PMC Article
  5. The SNARE-associated protein Sft2 functions in Imh1-mediated SNARE recycling transport upon ER stress. Lai CC, et al. Mol Biol Cell, 2023 Oct 1. PMID 37610835, Free PMC Article

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in retrograde transport, endosome to Golgi IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi trans cisterna IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in endomembrane system IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
Sft2p
NP_009448.1
  • Tetra-spanning membrane protein found mostly in the late Golgi; non-essential; can suppress some sed5 alleles; may be part of the transport machinery, but precise function is unknown; similar to mammalian syntaxin 5

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001134.8 Reference assembly

    Range
    24098..24745
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178342.1 → NP_009448.1  Sft2p

    See identical proteins and their annotated locations for NP_009448.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VPQ1, P38166
    UniProtKB/TrEMBL
    A6ZKK2, B3LNN2, B5VDP3, C7GSE3, C8Z3T9, G2W8R2, N1PAX5
    Conserved Domains (1) summary
    COG5102
    Location:7 → 214
    SFT2; Membrane protein involved in ER to Golgi transport [Intracellular trafficking and secretion]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P38166.1

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