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FDC1 putative phenylacrylic acid decarboxylase FDC1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 852152, updated on 11-May-2025
Official Symbol
FDC1
Official Full Name
putative phenylacrylic acid decarboxylase FDC1
Primary source
SGD:S000002947
Locus tag
YDR539W
See related
AllianceGenome:SGD:S000002947; FungiDB:YDR539W; VEuPathDB:YDR539W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables carboxy-lyase activity. Involved in cinnamic acid catabolic process and ferulate metabolic process. Located in cytoplasm. [provided by Alliance of Genome Resources, May 2025]
Orthologs
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See FDC1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (1512094..1513605)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene glucose-inactivated glycerol proton symporter STL1 Neighboring gene phenylacrylic acid decarboxylase PAD1 Neighboring gene Irc4p Neighboring gene carbonyl reductase (NADPH-dependent)

Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Exploring the substrate scope of ferulic acid decarboxylase (FDC1) from Saccharomyces cerevisiae. Nagy EZA, et al. Sci Rep, 2019 Jan 24. PMID 30679592, Free PMC Article
  2. Reducing phenolic off-flavors through CRISPR-based gene editing of the FDC1 gene in Saccharomyces cerevisiae x Saccharomyces eubayanus hybrid lager beer yeasts. Mertens S, et al. PLoS One, 2019. PMID 30625138, Free PMC Article
  3. PAD1 and FDC1 are essential for the decarboxylation of phenylacrylic acids in Saccharomyces cerevisiae. Mukai N, et al. J Biosci Bioeng, 2010 Jun. PMID 20471595
  4. Single nucleotide polymorphisms of PAD1 and FDC1 show a positive relationship with ferulic acid decarboxylation ability among industrial yeasts used in alcoholic beverage production. Mukai N, et al. J Biosci Bioeng, 2014 Jul. PMID 24507903
  5. Overexpression of PAD1 and FDC1 results in significant cinnamic acid decarboxylase activity in Saccharomyces cerevisiae. Richard P, et al. AMB Express, 2015. PMID 25852989, Free PMC Article

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. substrate scope of ferulic acid decarboxylase (FDC1) from Saccharomyces cerevisiae
    Title: Exploring the substrate scope of ferulic acid decarboxylase (FDC1) from Saccharomyces cerevisiae.
  2. PAD1 synthesizes a cofactor required by FDC (ferulic acid decarboxylase) for decarboxylase activity.
    Title: Isofunctional enzymes PAD1 and UbiX catalyze formation of a novel cofactor required by ferulic acid decarboxylase and 4-hydroxy-3-polyprenylbenzoic acid decarboxylase.
  3. study presents 3-dimensional structure of FDC1; crystallization with a decarboxylated reaction product identifies a large apolar cavity as the active site and suggests a catalytic mechanism for the nonoxidative decarboxylation reaction of aromatic substrates
    Title: Structure and Mechanism of Ferulic Acid Decarboxylase (FDC1) from Saccharomyces cerevisiae.
  4. examination of the contribution of the FDC1 (ferulic acid decarboxylase, YDR539W) gene to the decarboxylation of phenylacrylic acid using gene disruptants and the corresponding transformants in which the disrupted genes were recovered.
    Title: PAD1 and FDC1 are essential for the decarboxylation of phenylacrylic acids in Saccharomyces cerevisiae.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables carboxy-lyase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables carboxy-lyase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables carboxy-lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables carboxy-lyase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cinnamic acid catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cinnamic acid catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in cinnamic acid catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ferulate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ferulate metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within ferulate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in ferulate metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
putative phenylacrylic acid decarboxylase FDC1
NP_010828.1
  • Ferulic acid decarboxylase; involved in the decarboxylation of aromatic carboxylic acids such as phenylacrylic (cinnamic) acid, ferulic acid and coumaric acid and formation of the corresponding vinyl derivatives; overexpression of both Pad1p and Fdc1p increases decarboxylase activity due to the Pad1p-catalyzed formation of a diffusible cofactor required for Fdc1p activity; homolog of E. coli UbiD; GFP-fusion protein localizes to the cytoplasm in an HTP study

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    1512094..1513605
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180847.1 → NP_010828.1  TPA: putative phenylacrylic acid decarboxylase FDC1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010828.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VTF8, Q03034
    UniProtKB/TrEMBL
    A6ZZC4, B2NII1, B3LFD4, C7GST3, C8Z698, E9P8F1, E9P8F2
    Conserved Domains (1) summary
    TIGR00148
    Location:10 → 463
    TIGR00148; UbiD family decarboxylase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q03034.1

Gene LinkOut

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