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STL1 glucose-inactivated glycerol proton symporter STL1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 852149, updated on 5-Jul-2025
Official Symbol
STL1
Official Full Name
glucose-inactivated glycerol proton symporter STL1
Primary source
SGD:S000002944
Locus tag
YDR536W
See related
AllianceGenome:SGD:S000002944; FungiDB:YDR536W; VEuPathDB:YDR536W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables solute:proton symporter activity. Involved in glycerol transmembrane transport. Located in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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See STL1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (1508005..1509714)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene glutathione-independent methylglyoxalase Neighboring gene Fit1p Neighboring gene phenylacrylic acid decarboxylase PAD1 Neighboring gene putative phenylacrylic acid decarboxylase FDC1

Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. The STL1 gene of Saccharomyces cerevisiae is predicted to encode a sugar transporter-like protein. Zhao S, et al. Gene, 1994 Sep 2. PMID 8076821
  2. Expression and functional studies of genes involved in transport and metabolism of glycerol in Pachysolen tannophilus. Liu X, et al. Microb Cell Fact, 2013 Mar 21. PMID 23514356, Free PMC Article
  3. Long-term model predictive control of gene expression at the population and single-cell levels. Uhlendorf J, et al. Proc Natl Acad Sci U S A, 2012 Aug 28. PMID 22893687, Free PMC Article
  4. Saccharomyces cerevisiae glycerol/H+ symporter Stl1p is essential for cold/near-freeze and freeze stress adaptation. A simple recipe with high biotechnological potential is given. Tulha J, et al. Microb Cell Fact, 2010 Nov 3. PMID 21047428, Free PMC Article
  5. Glucose repression over Saccharomyces cerevisiae glycerol/H+ symporter gene STL1 is overcome by high temperature. Ferreira C, et al. FEBS Lett, 2007 May 1. PMID 17434487

See all (47) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The DNA-binding domain of Hot1 recognizes sequence 5'-GGGACAAA-3' located in the promoter of gene STL1.
    Title: The C-terminal region of the Hot1 transcription factor binds GGGACAAA-related sequences in the promoter of its target genes.
  2. results show the function of Stl1p and Fps1p transporters contributes to cell's ability to survive during transfer into state of anhydrobiosis; deletion of FPS1 decreases cell's tolerance of hyperosmotic stress; deletion of STL1 results in slight increase in cell size and increase in intracellular pH
    Title: The role of glycerol transporters in yeast cells in various physiological and stress conditions.
  3. Relief of glucose repression by high temperature at the level of Stl1p protein expression and activity.
    Title: Glucose repression over Saccharomyces cerevisiae glycerol/H+ symporter gene STL1 is overcome by high temperature.
  4. glycerol proton symporter in Saccharomyces cerevisiae is encoded by STL1
    Title: A member of the sugar transporter family, Stl1p is the glycerol/H+ symporter in Saccharomyces cerevisiae.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables carbohydrate:proton symporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables solute:proton symporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables solute:proton symporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in glycerol transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glycerol transmembrane transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in proton transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in transmembrane transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cell periphery HDA PubMed 
located_in fungal-type vacuole HDA PubMed 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
Preferred Names
glucose-inactivated glycerol proton symporter STL1
NP_010825.3
  • Glycerol proton symporter of the plasma membrane; subject to glucose-induced inactivation, strongly but transiently induced when cells are subjected to osmotic shock

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    1508005..1509714
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180844.3 → NP_010825.3  TPA: glucose-inactivated glycerol proton symporter STL1

    See identical proteins and their annotated locations for NP_010825.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VTF6, E9P950, P39932
    UniProtKB/TrEMBL
    C7GST5, G2WBR2, N1PAM1
    Conserved Domains (1) summary
    pfam00083
    Location:32 → 488
    Sugar_tr; Sugar (and other) transporter
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P39932.2

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