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HSP31 glutathione-independent methylglyoxalase [ Saccharomyces cerevisiae S288C ]

Gene ID: 852146, updated on 7-Jun-2026
Official Symbol
HSP31
Official Full Name
glutathione-independent methylglyoxalase
Primary source
SGD:S000002941
Locus tag
YDR533C
See related
AllianceGenome:SGD:S000002941; FungiDB:YDR533C; VEuPathDB:YDR533C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables glyoxalase III activity and protein folding chaperone. Involved in several processes, including cellular response to oxidative stress; chaperone-mediated protein folding; and methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione. Located in P-body and cytoplasmic stress granule. Used to study Parkinson's disease; cancer; and early-onset Parkinson's disease. [provided by Alliance of Genome Resources, Apr 2025]
Orthologs
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See HSP31 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (1501447..1502160, complement)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene pantothenate kinase Neighboring gene Kre28p Neighboring gene Fit1p Neighboring gene glucose-inactivated glycerol proton symporter STL1

Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Systematic analysis of HSP gene expression and effects on cell growth and survival at high hydrostatic pressure in Saccharomyces cerevisiae. Miura T, et al. Extremophiles, 2006 Aug. PMID 16489413
  2. Exploiting 3D structural templates for detection of metal-binding sites in protein structures. Goyal K, et al. Proteins, 2008 Mar. PMID 17847089
  3. Saccharomyces cerevisiae Hsp31p, a stress response protein conferring protection against reactive oxygen species. Skoneczna A, et al. Free Radic Biol Med, 2007 May 1. PMID 17395014
  4. Hsp31 Is a Stress Response Chaperone That Intervenes in the Protein Misfolding Process. Tsai CJ, et al. J Biol Chem, 2015 Oct 9. PMID 26306045, Free PMC Article
  5. Hsp31, a member of the DJ-1 superfamily, is a multitasking stress responder with chaperone activity. Aslam K, et al. Prion, 2016 Mar 3. PMID 27097320, Free PMC Article

See all (50) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Hsp31 has several biochemical activities including chaperone and detoxifying enzyme activities that modulate at various points of a stress pathway such as toxicity associated with protein misfolding.
    Title: Hsp31, a member of the DJ-1 superfamily, is a multitasking stress responder with chaperone activity.
  2. delineation of Hsp31's role in the chaperone cycle has implications for understanding the role of the DJ-1 superfamily in controlling misfolded proteins in neurodegenerative disease and cancer
    Title: The small heat shock protein Hsp31 cooperates with Hsp104 to modulate Sup35 prion aggregation.
  3. The Saccharomyces cerevisiae HSP31 orthologue of Parkinson's disease-associated DJ-1 is a multi-stress response protein protecting cells against toxic glycolytic products.
    Title: The budding yeast orthologue of Parkinson's disease-associated DJ-1 is a multi-stress response protein protecting cells against toxic glycolytic products.
  4. Hsp31 chaperone family controls the steady state level of misfolded substrate.
    Title: Absence of the Yeast Hsp31 Chaperones of the DJ-1 Superfamily Perturbs Cytoplasmic Protein Quality Control in Late Growth Phase.
  5. Hsp31 maintains cellular glutathione and NADPH levels, thus conferring protection against oxidative stress
    Title: Robust glyoxalase activity of Hsp31, a ThiJ/DJ-1/PfpI family member protein, is critical for oxidative stress resistance in Saccharomyces cerevisiae.
  6. the protective role of Hsp31 against cellular stress
    Title: Hsp31 Is a Stress Response Chaperone That Intervenes in the Protein Misfolding Process.
  7. We find that the Hsp31 genes are strongly induced in diauxic shift and in stationary phase.
    Title: Yeast DJ-1 superfamily members are required for diauxic-shift reprogramming and cell survival in stationary phase.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables glyoxalase III activity EXP
Inferred from Experiment
more info
 PubMed 
enables glyoxalase III activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glyoxalase III activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables glyoxalase III activity IEA
Inferred from Electronic Annotation
more info
  
enables protein folding chaperone IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in cellular response to nutrient levels IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to nutrient levels IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellular response to oxidative stress IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in methylglyoxal catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in methylglyoxal catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in protein folding IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in P-body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in P-body IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasmic stress granule HDA PubMed 
located_in cytoplasmic stress granule IDA
Inferred from Direct Assay
more info
 PubMed 
Preferred Names
glutathione-independent methylglyoxalase
NP_010822.1
  • Methylglyoxalase that converts methylglyoxal to D-lactate; involved in oxidative stress resistance, diauxic shift, and stationary phase survival; has similarity to E. coli Hsp31 and C. albicans Glx3p; member of the DJ-1/ThiJ/PfpI superfamily, which includes human DJ-1 involved in Parkinson's disease and cancer; exists as a dimer and contains a putative metal-binding site; protein abundance increases in response to DNA replication stress

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    1501447..1502160 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180841.1 → NP_010822.1  glutathione-independent methylglyoxalase

    See identical proteins and their annotated locations for NP_010822.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VTF4, E9P8V9, Q04432
    UniProtKB/TrEMBL
    A6ZZC0, B3LFD8, B5VH52, C8Z693, G2WBR0, N1P7K8
    Conserved Domains (1) summary
    cd03147
    Location:5 → 235
    GATase1_Ydr533c_like; Type 1 glutamine amidotransferase (GATase1)-like domain found in Saccharomyces cerevisiae Ydr533c protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q04432.1

Gene LinkOut

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