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CAB1 pantothenate kinase [ Saccharomyces cerevisiae S288C ]

Gene ID: 852144, updated on 3-Jun-2026
Official Symbol
CAB1
Official Full Name
pantothenate kinase
Primary source
SGD:S000002939
Locus tag
YDR531W
See related
AllianceGenome:SGD:S000002939; FungiDB:YDR531W; VEuPathDB:YDR531W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables pantothenate kinase activity. Involved in coenzyme A biosynthetic process and ergosterol metabolic process. Located in cytoplasm. Used to study pantothenate kinase-associated neurodegeneration. Human ortholog(s) of this gene implicated in cataract and pantothenate kinase-associated neurodegeneration. Orthologous to several human genes including PANK4 (pantothenate kinase 4 (inactive)). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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See CAB1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (1498232..1499335)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene ubiquinol--cytochrome-c reductase subunit 7 Neighboring gene bifunctional AP-4-A phosphorylase/ADP sulfurylase Neighboring gene Kre28p Neighboring gene glutathione-independent methylglyoxalase

Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Coenzyme A-synthesizing protein complex of Saccharomyces cerevisiae. Bucovaz ET, et al. Mol Cell Biochem, 1980 Mar 20. PMID 6247641
  2. Exploring Yeast as a Study Model of Pantothenate Kinase-Associated Neurodegeneration and for the Identification of Therapeutic Compounds. Ceccatelli Berti C, et al. Int J Mol Sci, 2020 Dec 30. PMID 33396642, Free PMC Article
  3. The coenzyme A-synthesizing protein complex and its proposed role in CoA biosynthesis in bakers' yeast. Bucovaz ET, et al. Biochimie, 1997 Dec. PMID 9523022
  4. The yeast pantothenate kinase Cab1 is a master regulator of sterol metabolism and of susceptibility to ergosterol biosynthesis inhibitors. Chiu JE, et al. J Biol Chem, 2019 Oct 4. PMID 31409644, Free PMC Article
  5. The antimalarial activity of the pantothenamide α-PanAm is via inhibition of pantothenate phosphorylation. Chiu JE, et al. Sci Rep, 2017 Oct 27. PMID 29079738, Free PMC Article

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Exploring Yeast as a Study Model of Pantothenate Kinase-Associated Neurodegeneration and for the Identification of Therapeutic Compounds.
    Title: Exploring Yeast as a Study Model of Pantothenate Kinase-Associated Neurodegeneration and for the Identification of Therapeutic Compounds.
  2. Here, we show that the pantothenate kinase Cab1p, which catalyzes the first step in the metabolism of pantothenic acid for CoA biosynthesis in budding yeast (Saccharomyces cerevisiae), significantly regulates the levels of sterol intermediates and the activities of ergosterol biosynthesis-targeting antifungals.
    Title: The yeast pantothenate kinase Cab1 is a master regulator of sterol metabolism and of susceptibility to ergosterol biosynthesis inhibitors.
  3. Complementation studies by bacterial and mammalian genes showed that YDR531W encodes a genuine pantothenate kinase (new gene designation: CAB1, "coenzyme A biosynthesis").
    Title: Genetic analysis of coenzyme A biosynthesis in the yeast Saccharomyces cerevisiae: identification of a conditional mutation in the pantothenate kinase gene CAB1.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables pantothenate kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables pantothenate kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables pantothenate kinase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables pantothenate kinase activity RCA
inferred from Reviewed Computational Analysis
more info
  
Process Evidence Code Pubs
involved_in coenzyme A biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in coenzyme A biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in coenzyme A biosynthetic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in coenzyme A biosynthetic process RCA
inferred from Reviewed Computational Analysis
more info
  
involved_in ergosterol metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytosol RCA
inferred from Reviewed Computational Analysis
more info
  
located_in nucleus HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
pantothenate kinase
NP_010820.3
  • Pantothenate kinase, ATP:D-pantothenate 4'-phosphotransferase; cytoplasmic enzyme that catalyzes the first committed step in the universal biosynthetic pathway for coenzyme A (CoA) synthesis; transcription is regulated by Upc2p via a sterol response element; overexpressed human homologs, PANK1 and PANK3, complement yeast hypomorphic alleles, while PANK2, a gene implicated in pantothenate-kinase associated neurodegeneration, partially complements after the mitochondrial transit peptide is removed

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    1498232..1499335
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180839.3 → NP_010820.3  pantothenate kinase

    See identical proteins and their annotated locations for NP_010820.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VTF2, Q04430
    UniProtKB/TrEMBL
    B5VH50, C7GKW2, G2WBQ8, N1P7T0
    Conserved Domains (1) summary
    COG5146
    Location:1 → 367
    PanK; Pantothenate kinase [Coenzyme transport and metabolism]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q04430.1

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