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AGE1 GTPase-activating protein AGE1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 852136, updated on 18-Jan-2023

Summary

Gene symbol
AGE1
Gene description
GTPase-activating protein AGE1
Primary source
SGD:S000002932
Locus tag
YDR524C
See related
AllianceGenome:SGD:S000002932
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
SAT1
Summary
Enables GTPase activator activity and phospholipid binding activity. Involved in endoplasmic reticulum to Golgi vesicle-mediated transport and intra-Golgi vesicle-mediated transport. Located in endosome and trans-Golgi network. Orthologous to human ACAP1 (ArfGAP with coiled-coil, ankyrin repeat and PH domains 1) and ACAP3 (ArfGAP with coiled-coil, ankyrin repeat and PH domains 3). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

See AGE1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (1487542..1488990, complement)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Sps2p Neighboring gene putative serine/threonine protein kinase SPS1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by GO

Function Evidence Code Pubs
enables GTPase activator activity IDA
Inferred from Direct Assay
more info
PubMed 
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables phospholipid binding IDA
Inferred from Direct Assay
more info
PubMed 
enables zinc ion binding RCA
inferred from Reviewed Computational Analysis
more info
PubMed 
Process Evidence Code Pubs
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in intra-Golgi vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in intra-Golgi vesicle-mediated transport IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in endosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in endosome IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in trans-Golgi network IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in trans-Golgi network IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
GTPase-activating protein AGE1
NP_010812.3
  • ADP-ribosylation factor (ARF) GTPase activating protein (GAP) effector; involved in the secretory and endocytic pathways; contains C2C2H2 cysteine/histidine motif

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    1487542..1488990 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180832.3NP_010812.3  TPA: GTPase-activating protein AGE1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010812.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VTE4, Q04412
    UniProtKB/TrEMBL
    A0A8H8UP51
    Conserved Domains (1) summary
    COG5347
    Location:164480
    COG5347; GTPase-activating protein that regulates ARFs (ADP-ribosylation factors), involved in ARF-mediated vesicular transport [Intracellular trafficking and secretion]