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VPS72 Vps72p [ Saccharomyces cerevisiae S288C ]

Gene ID: 852096, updated on 14-Nov-2024

Summary

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Official Symbol
VPS72
Official Full Name
Vps72p
Primary source
SGD:S000002893
Locus tag
YDR485C
See related
AllianceGenome:SGD:S000002893; FungiDB:YDR485C; VEuPathDB:YDR485C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
SWC2
Summary
Enables histone binding activity. Involved in chromatin remodeling. Located in cytoplasm and nucleus. Part of Swr1 complex. Orthologous to human VPS72 (vacuolar protein sorting 72 homolog). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See VPS72 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (1424820..1427207, complement)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene alpha-1,2-mannosyltransferase KRE2 Neighboring gene Vps52p Neighboring gene Vps60p Neighboring gene 3,4-dihydroxy-2-butanone-4-phosphate synthase RIB3

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. SWR-C and INO80 chromatin remodelers recognize nucleosome-free regions near +1 nucleosomes. Yen K, et al. Cell, 2013 Sep 12. PMID 24034248, Free PMC Article
  2. Recognition of the inherently unstable H2A nucleosome by Swc2 is a major determinant for unidirectional H2A.Z exchange. Dai L, et al. Cell Rep, 2021 May 25. PMID 34038732
  3. Mutations in non-acid patch residues disrupt H2A.Z's association with chromatin through multiple mechanisms. Wood TJ, et al. PLoS One, 2013. PMID 24098487, Free PMC Article
  4. The SWR1 histone replacement complex causes genetic instability and genome-wide transcription misregulation in the absence of H2A.Z. Morillo-Huesca M, et al. PLoS One, 2010 Aug 12. PMID 20711347, Free PMC Article
  5. Roles for H2A.Z and its acetylation in GAL1 transcription and gene induction, but not GAL1-transcriptional memory. Halley JE, et al. PLoS Biol, 2010 Jun 22. PMID 20582323, Free PMC Article

See all (108) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Swc2 binds directly to and is essential for transfer of H2AZ.
    Title: Swc2 is a widely conserved H2AZ-binding module essential for ATP-dependent histone exchange.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables histone binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in chromatin organization IEA
Inferred from Electronic Annotation
more info
  
involved_in chromatin remodeling IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in chromatin remodeling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of Swr1 complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm HDA PubMed 
located_in nucleus HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Vps72p
NP_010773.4
  • Htz1p-binding component of the SWR1 complex; exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; may function as a lock that prevents removal of H2AZ from nucleosomes; required for vacuolar protein sorting

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    1424820..1427207 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180793.3 → NP_010773.4  TPA: Vps72p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010773.4

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VTA8, Q03388
    UniProtKB/TrEMBL
    B3LFI1, C7GKS3
    Conserved Domains (2) summary
    smart00993
    Location:708 → 737
    YL1_C; YL1 nuclear protein C-terminal domain
    pfam05764
    Location:21 → 292
    YL1; YL1 nuclear protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q03388.2

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