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PHO8 [ Saccharomyces cerevisiae S288C ]

Gene ID: 852092, updated on 22-Aug-2024

Summary

Official Symbol
PHO8
Primary source
FungiDB:YDR481C
Locus tag
YDR481C
See related
SGD:S000002889; AllianceGenome:SGD:S000002889; VEuPathDB:YDR481C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables alkaline phosphatase activity. Involved in nicotinamide nucleotide metabolic process and protein dephosphorylation. Located in fungal-type vacuole membrane. Used to study several diseases, including bone disease (multiple); cryptorchidism; germ cell cancer (multiple); hypophosphatasia (multiple); and primary biliary cholangitis. Human ortholog(s) of this gene implicated in adult hypophosphatasia; childhood hypophosphatasia; hypophosphatasia; infantile hypophosphatasia; and inflammatory bowel disease. Orthologous to several human genes including ALPL (alkaline phosphatase, biomineralization associated) and ALPP (alkaline phosphatase, placental). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (1418550..1420250, complement)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Pex29p Neighboring gene Dig2p Neighboring gene U2-type spliceosomal complex subunit CWC21 Neighboring gene alpha-1,2-mannosyltransferase KRE2

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables alkaline phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables alkaline phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables alkaline phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables fructose-2,6-bisphosphate 6-phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables zinc ion binding RCA
inferred from Reviewed Computational Analysis
more info
PubMed 
Process Evidence Code Pubs
involved_in dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in nicotinamide nucleotide metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within nucleotide catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in organophosphate metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in phosphate-containing compound metabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in fungal-type vacuole membrane HDA PubMed 
is_active_in fungal-type vacuole membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in fungal-type vacuole membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in vacuolar membrane IEA
Inferred from Electronic Annotation
more info
 
located_in vacuole IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
alkaline phosphatase PHO8
NP_010769.3
  • Repressible vacuolar alkaline phosphatase; controls polyphosphate content; regulated by levels of Pi and by Pho4p, Pho9p, Pho80p, Pho81p and Pho85p; dephosphorylates phosphotyrosyl peptides; contributes to NAD+ metabolism by producing nicotinamide riboside from NMN

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    1418550..1420250 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180789.3NP_010769.3  TPA: alkaline phosphatase PHO8 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010769.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VTA4, E9P949, P11491, Q03374
    UniProtKB/TrEMBL
    B3LFI5, C7GKS0, C8Z639, N1P5R2
    Conserved Domains (1) summary
    COG1785
    Location:8530
    PhoA; Alkaline phosphatase [Inorganic ion transport and metabolism, General function prediction only]