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UGO1 Ugo1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 852081, updated on 22-Sep-2022

Summary

Gene symbol
UGO1
Gene description
Ugo1p
Primary source
SGD:S000002878
Locus tag
YDR470C
See related
AllianceGenome:SGD:S000002878
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to enable thiamine transmembrane transporter activity. Involved in mitochondrial fusion. Is integral component of mitochondrial outer membrane. Used to study Leigh disease. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

See UGO1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (1399706..1401214, complement)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Tlg1p Neighboring gene Sdc1p Neighboring gene ribosomal 60S subunit protein L27B Neighboring gene ncRNA

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

  • Homologs of the UGO1 gene: The UGO1 gene is conserved in S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, and N.crassa.

Gene Ontology Provided by GO

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
enables thiamine transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in mitochondrial fusion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in thiamine pyrophosphate transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in mitochondrial inner membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in mitochondrial outer membrane HDA PubMed 
located_in mitochondrial outer membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrial outer membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrion HDA PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
Ugo1p
NP_010758.3
  • Outer membrane component of the mitochondrial fusion machinery; binds to Fzo1p and Mgm1p to link these two GTPases during mitochondrial fusion; involved in fusion of both the outer and inner membranes; facilitates dimerization of Fzo1p during fusion; import into the outer membrane is mediated by Tom70p and Mim1p; has similarity to carrier proteins but likely not a transporter; similar to human SLC25A46 implicated in optic atroprophy spectrum disorder and Leigh syndrome

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    1399706..1401214 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180778.2NP_010758.3  TPA: Ugo1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010758.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VT94, Q03327
    UniProtKB/TrEMBL
    A0A6C1DQR3, A0A8H8UP03, N1P7C5