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PPZ2 salt homeostasis regulator [ Saccharomyces cerevisiae S288C ]

Gene ID: 852046, updated on 5-Jul-2025
Official Symbol
PPZ2
Official Full Name
salt homeostasis regulator
Primary source
SGD:S000002844
Locus tag
YDR436W
See related
AllianceGenome:SGD:S000002844; FungiDB:YDR436W; VEuPathDB:YDR436W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to enable protein serine/threonine phosphatase activity. Involved in intracellular sodium ion homeostasis. Predicted to be active in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (1334821..1336953)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene GPI-anchor transamidase GPI17 Neighboring gene leucine carboxy methyltransferase Neighboring gene phosphatidylinositol N-acetylglucosaminyltransferase GPI19 Neighboring gene Thi74p

Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. The PPZ protein phosphatases are involved in the maintenance of osmotic stability of yeast cells. Posas F, et al. FEBS Lett, 1993 Mar 8. PMID 8382634
  2. Both isoforms of protein phosphatase Z are essential for the maintenance of cell size and integrity in Saccharomyces cerevisiae in response to osmotic stress. Hughes V, et al. Eur J Biochem, 1993 Aug 15. PMID 8396031
  3. The PPZ protein phosphatases are important determinants of salt tolerance in yeast cells. Posas F, et al. J Biol Chem, 1995 Jun 2. PMID 7768897
  4. [The protein complex Ppz1p/Hal3p and nonsense suppression efficiency in the yeast Saccharomyces cerevisiae]. Ivanov MS, et al. Mol Biol (Mosk), 2010 Nov-Dec. PMID 21290823
  5. Regulation of salt tolerance in fission yeast by a protein-phosphatase-Z-like Ser/Thr protein phosphatase. Balcells L, et al. Eur J Biochem, 1997 Dec 1. PMID 9428701

See all (58) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine phosphatase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in intracellular sodium ion homeostasis IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular sodium ion homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
Preferred Names
salt homeostasis regulator
NP_010724.1
  • Serine/threonine protein phosphatase Z, isoform of Ppz1p; involved in regulation of potassium transport, which affects osmotic stability, cell cycle progression, and halotolerance

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    1334821..1336953
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180744.1 → NP_010724.1  TPA: salt homeostasis regulator

    See identical proteins and their annotated locations for NP_010724.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VT63, P33329
    UniProtKB/TrEMBL
    B3LFM3, C8Z5Z6, N1P5L5
    Conserved Domains (1) summary
    cd07414
    Location:397 → 688
    MPP_PP1_PPKL; PP1, PPKL (PP1 and kelch-like) enzymes, and related proteins, metallophosphatase domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P33329.4

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