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HPT1 hypoxanthine phosphoribosyltransferase [ Saccharomyces cerevisiae S288C ]

Gene ID: 852008, updated on 9-Sep-2018

Summary

Gene symbol
HPT1
Gene description
hypoxanthine phosphoribosyltransferase
Primary source
SGD:S000002807
Locus tag
YDR399W
Gene type
protein coding
RNA name
hypoxanthine phosphoribosyltransferase
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
BRA6

Genomic context

See HPT1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (1270068..1270733)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene negative cofactor 2 transcription regulator complex subunit NCB2 Neighboring gene Utp5p Neighboring gene trifunctional uridine nucleosidase/nicotinamide riboside hydrolase/nicotinic acid riboside hydrolase Neighboring gene putative cytochrome P450

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by GO

Function Evidence Code Pubs
guanine phosphoribosyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
hypoxanthine phosphoribosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
hypoxanthine phosphoribosyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
hypoxanthine phosphoribosyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
hypoxanthine phosphoribosyltransferase activity IGI
Inferred from Genetic Interaction
more info
PubMed 
hypoxanthine phosphoribosyltransferase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
phosphomannomutase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
transferase activity, transferring glycosyl groups IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
GMP salvage IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
GMP salvage IDA
Inferred from Direct Assay
more info
PubMed 
GMP salvage IGI
Inferred from Genetic Interaction
more info
PubMed 
GMP salvage IMP
Inferred from Mutant Phenotype
more info
PubMed 
IMP salvage IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
IMP salvage IDA
Inferred from Direct Assay
more info
PubMed 
IMP salvage IEA
Inferred from Electronic Annotation
more info
 
XMP salvage IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
hypoxanthine metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleoside metabolic process IEA
Inferred from Electronic Annotation
more info
 
purine ribonucleoside salvage IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm HDA PubMed 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
nucleus HDA PubMed 
nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
hypoxanthine phosphoribosyltransferase
NP_010687.3
  • Dimeric hypoxanthine-guanine phosphoribosyltransferase; catalyzes the transfer of the phosphoribosyl portion of 5-phosphoribosyl-alpha-1-pyrophosphate to a purine base (either guanine or hypoxanthine) to form pyrophosphate and a purine nucleotide (either guanosine monophosphate or inosine monophosphate); mutations in the human homolog HPRT1 can cause Lesch-Nyhan syndrome and Kelley-Seegmiller syndrome

NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    1270068..1270733
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180707.3NP_010687.3  TPA: hypoxanthine phosphoribosyltransferase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010687.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q04178
    Conserved Domains (1) summary
    COG2236
    Location:3206
    Hpt1; Hypoxanthine phosphoribosyltransferase [Coenzyme transport and metabolism]
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