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MUS81 Mus81p [ Saccharomyces cerevisiae S288C ]

Gene ID: 851994, updated on 18-Sep-2024

Summary

Official Symbol
MUS81
Official Full Name
Mus81p
Primary source
SGD:S000002794
Locus tag
YDR386W
See related
AllianceGenome:SGD:S000002794; FungiDB:YDR386W; VEuPathDB:YDR386W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
SLX3
Summary
Enables enzyme inhibitor activity. Contributes to crossover junction endodeoxyribonuclease activity. Involved in DNA metabolic process and negative regulation of helicase activity. Located in nucleus. Part of Holliday junction resolvase complex. Orthologous to human MUS81 (MUS81 structure-specific endonuclease subunit). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

See MUS81 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (1246084..1247982)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene putative ammonium permease ATO3 Neighboring gene elongation factor 2 Neighboring gene Cin10p Neighboring gene amphiphysin

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables 3'-flap endonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
contributes_to DNA endonuclease activity IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to crossover junction DNA endonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
 
contributes_to crossover junction DNA endonuclease activity IDA
Inferred from Direct Assay
more info
PubMed 
enables crossover junction DNA endonuclease activity IEA
Inferred from Electronic Annotation
more info
 
enables endonuclease activity IEA
Inferred from Electronic Annotation
more info
 
enables enzyme inhibitor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in DNA catabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in DNA damage response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in DNA recombination IEA
Inferred from Electronic Annotation
more info
 
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
 
involved_in DNA topological change IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in double-strand break repair IEA
Inferred from Electronic Annotation
more info
 
involved_in double-strand break repair via break-induced replication IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in double-strand break repair via break-induced replication IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in double-strand break repair via break-induced replication IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in meiotic cell cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in mitotic intra-S DNA damage checkpoint signaling IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in reciprocal meiotic recombination IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in resolution of meiotic recombination intermediates IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in resolution of meiotic recombination intermediates IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
part_of Holliday junction resolvase complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of Holliday junction resolvase complex IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus IMP
Inferred from Mutant Phenotype
more info
PubMed 

General protein information

Preferred Names
Mus81p
NP_010674.3
  • Subunit of structure-specific Mms4p-Mus81p endonuclease; cleaves branched DNA and DNA-protein cross-links; involved in DNA repair, replication fork stability, and joint molecule formation/resolution during meiotic recombination; promotes template switching during break-induced replication (BIR), causing non-reciprocal translocations (NRTs); helix-hairpin-helix protein; phosphorylation of non-catalytic subunit Mms4p by Cdc28p and Cdc5p during mitotic cell cycle activates function of Mms4p-Mus81p

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    1246084..1247982
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180694.3NP_010674.3  TPA: Mus81p [Saccharomyces cerevisiae S288C]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VT20, Q04149
    UniProtKB/TrEMBL
    A6ZYY7, B3LFR4, C7GSD6, C8Z5V0, N1P8S9
    Conserved Domains (2) summary
    COG1948
    Location:314601
    MUS81; ERCC4-type nuclease [Replication, recombination and repair]
    cd21036
    Location:132224
    WH_MUS81; winged helix domain found in crossover junction endonuclease MUS81 and similar proteins