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CDC40 Cdc40p [ Saccharomyces cerevisiae S288C ]

Gene ID: 851968, updated on 5-Nov-2017
Gene symbol
CDC40
Gene description
Cdc40p
Primary source
SGD:S000002772
Locus tag
YDR364C
Gene type
protein coding
RNA name
Cdc40p
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288c)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
PRP17; SLT15; SLU4
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (1202843..1204210, complement)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene tRNA Neighboring gene proteasome regulatory particle lid subunit SEM1 Neighboring gene Esf1p Neighboring gene gag protein Neighboring gene gag-pol fusion protein

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Spliceosome, organism-specific biosystem (from KEGG)
    Spliceosome, organism-specific biosystemAfter transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, th...
  • Spliceosome, conserved biosystem (from KEGG)
    Spliceosome, conserved biosystemAfter transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, th...
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by GO

Function Evidence Code Pubs
contributes_to second spliceosomal transesterification activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
RNA splicing IEA
Inferred from Electronic Annotation
more info
 
generation of catalytic spliceosome for second transesterification step IGI
Inferred from Genetic Interaction
more info
PubMed 
generation of catalytic spliceosome for second transesterification step IMP
Inferred from Mutant Phenotype
more info
PubMed 
mRNA 3'-splice site recognition IGI
Inferred from Genetic Interaction
more info
PubMed 
mRNA branch site recognition IGI
Inferred from Genetic Interaction
more info
PubMed 
mRNA processing IEA
Inferred from Electronic Annotation
more info
 
mRNA splicing, via spliceosome IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
catalytic step 2 spliceosome IEA
Inferred from Electronic Annotation
more info
 
nuclear periphery IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IEA
Inferred from Electronic Annotation
more info
 
spliceosomal complex IDA
Inferred from Direct Assay
more info
PubMed 
spliceosomal complex IEA
Inferred from Electronic Annotation
more info
 
Names
Cdc40p
NP_010652.3
  • Pre-mRNA splicing factor; important for catalytic step II of pre-mRNA splicing and plays a role in cell cycle progression, particularly at the G1/S phase transition; required for DNA synthesis during mitosis and meiosis; has WD repeats; thermosensitivity of the cdc40 null mutant is functionally complemented by a chimeric construct containing the N-terminal 156 amino acids of yeast Cdc40p fused to the C-terminal two thirds (297 amino acids) of human CDC40

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    1202843..1204210 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180672.3NP_010652.3  TPA: Cdc40p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010652.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P40968
    Conserved Domains (2) summary
    cd00200
    Location:154408
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:166204
    7WD40; WD40 repeat [structural motif]
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