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SPC110 Spc110p [ Saccharomyces cerevisiae S288C ]

Gene ID: 851957, updated on 4-Feb-2024

Summary

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Gene symbol
SPC110
Gene description
Spc110p
Primary source
SGD:S000002764
Locus tag
YDR356W
See related
AllianceGenome:SGD:S000002764
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
NUF1; XCM1
Summary
Enables calmodulin binding activity. A structural constituent of cytoskeleton. Involved in several processes, including gamma-tubulin complex localization to nuclear side of mitotic spindle pole body; karyogamy involved in conjugation with cellular fusion; and positive regulation of microtubule nucleation. Located in central plaque of spindle pole body; inner plaque of spindle pole body; and nucleus. Human ortholog(s) of this gene implicated in autosomal recessive limb-girdle muscular dystrophy; congenital merosin-deficient muscular dystrophy 1A; muscular dystrophy; and myopia. Orthologous to human LAMA2 (laminin subunit alpha 2). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See SPC110 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (1186107..1188941)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene thioredoxin-disulfide reductase TRR1 Neighboring gene anthranilate phosphoribosyltransferase Neighboring gene Cnl1p Neighboring gene ubiquitin-binding protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Microtubule pivoting enables mitotic spindle assembly in S. cerevisiae. Fong KK, et al. J Cell Biol, 2021 Mar 1. PMID 33464308, Free PMC Article
  2. The Saccharomyces cerevisiae spindle pole body is a dynamic structure. Yoder TJ, et al. Mol Biol Cell, 2003 Aug. PMID 12925780, Free PMC Article
  3. Identification and characterization of the KlCMD1 gene encoding Kluyveromyces lactis calmodulin. Rayner TF, et al. Yeast, 1998 Jun 30. PMID 9818725
  4. Identification of an Spc110p-related protein in vertebrates. Tassin AM, et al. J Cell Sci, 1997 Oct. PMID 9372442
  5. The 110-kD spindle pole body component of Saccharomyces cerevisiae is a phosphoprotein that is modified in a cell cycle-dependent manner. Friedman DB, et al. J Cell Biol, 1996 Mar. PMID 8603921, Free PMC Article

See all (99) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Phosphosites of the yeast centrosome component Spc110 contribute to cell cycle progression and mitotic exit.
    Title: Phosphosites of the yeast centrosome component Spc110 contribute to cell cycle progression and mitotic exit.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables calmodulin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein-containing complex binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein-containing complex binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables structural constituent of cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of cytoskeleton IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in gamma-tubulin complex localization to nuclear side of mitotic spindle pole body IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in gamma-tubulin complex localization to nuclear side of mitotic spindle pole body IPI
Inferred from Physical Interaction
more info
 PubMed 
involved_in karyogamy involved in conjugation with cellular fusion IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in karyogamy involved in conjugation with cellular fusion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic spindle elongation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of microtubule nucleation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein localization to mitotic spindle pole body IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein-containing complex assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein-containing complex assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in central plaque of spindle pole body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in inner plaque of spindle pole body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus HDA PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in spindle pole body IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Spc110p
NP_010643.3
  • Inner plaque spindle pole body (SPB) component; gamma-tubulin small complex (gamma-TuSC) receptor that interacts with Spc98p to recruit the complex to the nuclear side of the SPB, connecting nuclear microtubules to the SPB; promotes gamma-TuSC assembly and oligomerization to initiate microtubule nucleation; interacts with Tub4p-complex and calmodulin; phosphorylated by Mps1p in cell cycle-dependent manner; ortholog of human pericentrin (kendrin)

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    1186107..1188941
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180664.3 → NP_010643.3  TPA: Spc110p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010643.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    B3LFU6, C8Z5R8, D6VSY5, P32380
    UniProtKB/TrEMBL
    A0A8H8UNQ3, B5VGN7, N1P705
    Conserved Domains (2) summary
    TIGR02168
    Location:196 → 793
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam18520
    Location:893 → 944
    Spc110_C; Spindle pole body component 110 C-terminal domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P32380.1

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