IRC3 double-stranded DNA-dependent ATPase [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: IRC3
Official Full Name: double-stranded DNA-dependent ATPase
Primary source: SGD:S000002740
Locus tag: YDR332W
See related: AllianceGenome:SGD:S000002740; FungiDB:YDR332W; VEuPathDB:YDR332W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables Y-form DNA binding activity; double-stranded DNA helicase activity; and forked DNA-dependent helicase activity. Involved in mitochondrial DNA metabolic process. Acts upstream of or within regulation of mitochondrial translational elongation. Located in mitochondrial matrix. [provided by Alliance of Genome Resources, Jul 2025]
Orthologs: all
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Chromosome IV - NC_001136.10 Genomic Context describing neighboring genes

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables Y-form DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables Y-form DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables double-stranded DNA helicase activity	IBA Inferred from Biological aspect of Ancestor more info
enables double-stranded DNA helicase activity	IDA Inferred from Direct Assay more info	PubMed
enables forked DNA-dependent helicase activity	IBA Inferred from Biological aspect of Ancestor more info
enables forked DNA-dependent helicase activity	IDA Inferred from Direct Assay more info	PubMed
enables hydrolase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in mitochondrial DNA metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of mitochondrial translational elongation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in mitochondrial matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial matrix	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

NP_010619.3

Double-stranded DNA-dependent helicase of the DExH/D-box family; branch point-binding helicase that preferentially unwinds the nascent lagging strand with a 3' to 5' polarity at a replication fork; contains double-stranded DNA translocase activity; responsible for DNA branch migration; required for maintenance of the mitochondrial (mt) genome; localizes to the mitochondrial matrix; monomeric

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