GPI8 GPI-anchor transamidase [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: GPI8
Official Full Name: GPI-anchor transamidase
Primary source: SGD:S000002739
Locus tag: YDR331W
See related: AllianceGenome:SGD:S000002739; FungiDB:YDR331W; VEuPathDB:YDR331W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables GPI-anchor transamidase activity. Involved in attachment of GPI anchor to protein. Located in endoplasmic reticulum membrane. Part of GPI-anchor transamidase complex. Orthologous to human PIGK (phosphatidylinositol glycan anchor biosynthesis class K). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs: all
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Chromosome IV - NC_001136.10 Genomic Context describing neighboring genes

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The soluble domains of Gpi8 and Gaa1, two subunits of glycosylphosphatidylinositol transamidase, assemble into a complex.
Title: The soluble domains of Gpi8 and Gaa1, two subunits of glycosylphosphatidylinositol transamidase (GPI-T), assemble into a complex.
analysis of truncation of Gpi8p of Saccharomyces cerevisiae GPI transamidase
Title: Truncation of the caspase-related subunit (Gpi8p) of Saccharomyces cerevisiae GPI transamidase: dimerization revealed.

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables GPI-anchor transamidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GPI-anchor transamidase activity	IEA Inferred from Electronic Annotation more info
enables GPI-anchor transamidase activity	IGI Inferred from Genetic Interaction more info	PubMed
enables peptidase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in GPI anchor biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in attachment of GPI anchor to protein	IBA Inferred from Biological aspect of Ancestor more info
involved_in attachment of GPI anchor to protein	IEA Inferred from Electronic Annotation more info
involved_in attachment of GPI anchor to protein	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in attachment of GPI anchor to protein	ISS Inferred from Sequence or Structural Similarity more info
involved_in attachment of GPI anchor to protein	NAS Non-traceable Author Statement more info	PubMed
involved_in fungal-type cell wall organization	NAS Non-traceable Author Statement more info	PubMed
involved_in proteolysis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of GPI-anchor transamidase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of GPI-anchor transamidase complex	IDA Inferred from Direct Assay more info	PubMed
part_of GPI-anchor transamidase complex	IEA Inferred from Electronic Annotation more info
part_of GPI-anchor transamidase complex	IPI Inferred from Physical Interaction more info	PubMed
located_in endoplasmic reticulum	HDA more info	PubMed
located_in endoplasmic reticulum membrane	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	NAS Non-traceable Author Statement more info	PubMed

NP_010618.1

Catalytic subunit of the ER membrane GPI transamidase complex; involved in adding glycosylphosphatidylinositol (GPI) anchors to newly synthesized proteins; luminally-oriented type I integral membrane glycoprotein of the ER; human PIGK protein is a functional homolog

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