Format

Send to:

Choose Destination

GPI8 GPI-anchor transamidase [ Saccharomyces cerevisiae S288C ]

Gene ID: 851931, updated on 25-Jan-2022

Summary

Gene symbol
GPI8
Gene description
GPI-anchor transamidase
Primary source
SGD:S000002739
Locus tag
YDR331W
See related
AllianceGenome:SGD:S000002739
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables GPI-anchor transamidase activity. Involved in attachment of GPI anchor to protein. Located in endoplasmic reticulum membrane. Part of GPI-anchor transamidase complex. Orthologous to human PIGK (phosphatidylinositol glycan anchor biosynthesis class K). [provided by Alliance of Genome Resources, Nov 2021]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See GPI8 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (1129588..1130823)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Pex3p Neighboring gene Ubx5p Neighboring gene double-stranded DNA-dependent ATPase Neighboring gene Rqc1p

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

  • Homologs of the GPI8 gene: The GPI8 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, A.thaliana, rice, and frog.

Gene Ontology Provided by GO

Function Evidence Code Pubs
enables GPI-anchor transamidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables GPI-anchor transamidase activity IEA
Inferred from Electronic Annotation
more info
 
enables GPI-anchor transamidase activity IGI
Inferred from Genetic Interaction
more info
PubMed 
enables cysteine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in GPI anchor biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in attachment of GPI anchor to protein IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in attachment of GPI anchor to protein IEA
Inferred from Electronic Annotation
more info
 
involved_in attachment of GPI anchor to protein IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein localization to cell surface IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of GPI-anchor transamidase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of GPI-anchor transamidase complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of GPI-anchor transamidase complex IEA
Inferred from Electronic Annotation
more info
 
located_in endoplasmic reticulum HDA PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
GPI-anchor transamidase
NP_010618.1
  • Catalytic subunit of the ER membrane GPI transamidase complex; involved in adding glycosylphosphatidylinositol (GPI) anchors to newly synthesized proteins; luminally-oriented type I integral membrane glycoprotein of the ER; human PIGK protein is a functional homolog

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    1129588..1130823
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180639.1NP_010618.1  TPA: GPI-anchor transamidase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010618.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P49018
    Conserved Domains (1) summary
    COG5206
    Location:2407
    GPI8; Glycosylphosphatidylinositol transamidase (GPIT), subunit GPI8 [Posttranslational modification, protein turnover, chaperones]
Support Center