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SRB7 Srb7p [ Saccharomyces cerevisiae S288C ]

Gene ID: 851903, updated on 18-Sep-2024

Summary

Official Symbol
SRB7
Official Full Name
Srb7p
Primary source
SGD:S000002716
Locus tag
YDR308C
See related
AllianceGenome:SGD:S000002716; FungiDB:YDR308C; VEuPathDB:YDR308C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
MED21; SSX1
Summary
Enables RNA polymerase II-specific DNA-binding transcription factor binding activity; transcription coactivator activity; and transcription corepressor activity. Involved in negative regulation of transcription by RNA polymerase II and positive regulation of transcription by RNA polymerase II. Part of core mediator complex and mediator complex. Orthologous to human MED21 (mediator complex subunit 21). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

See SRB7 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (1078027..1078449, complement)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene tRNA-Val Neighboring gene putative dolichyl-phosphate-mannose--protein mannosyltransferase Neighboring gene Gic2p Neighboring gene Sum1p

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General protein information

Preferred Names
Srb7p
NP_010594.3
  • Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; target of the global repressor Tup1p

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    1078027..1078449 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180616.3NP_010594.3  TPA: Srb7p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010594.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VST7, P47822
    UniProtKB/TrEMBL
    A6ZYQ6, B3LFY8, C7GQV8, C8Z5L9, G2WB46, N1PAH5
    Conserved Domains (1) summary
    pfam11221
    Location:1131
    Med21; Subunit 21 of Mediator complex