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IFITM1 interferon induced transmembrane protein 1 [ Homo sapiens (human) ]

Gene ID: 8519, updated on 28-Jun-2020

Summary

Official Symbol
IFITM1provided by HGNC
Official Full Name
interferon induced transmembrane protein 1provided by HGNC
Primary source
HGNC:HGNC:5412
See related
Ensembl:ENSG00000185885 MIM:604456
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
9-27; CD225; IFI17; LEU13; DSPA2a
Expression
Ubiquitous expression in spleen (RPKM 191.9), endometrium (RPKM 153.8) and 24 other tissues See more
Orthologs

Genomic context

See IFITM1 in Genome Data Viewer
Location:
11p15.5
Exon count:
2
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (314040..315272)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (313991..315272)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene mitochondrial ribosomal protein S24 pseudogene 1 Neighboring gene interferon induced transmembrane protein 2 Neighboring gene interferon induced transmembrane protein 3 Neighboring gene uncharacterized LOC105376504

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
HIV-1 incorporates IFITM1 into virions but this incorporation does not strictly correlate with the phenotype of IFITM inhibition of HIV-1 cell-to-cell infection PubMed
Knockdown of IFITM1/2/3 by siRNA enhances virus transmission to target cells and the production of virions in CD4+ T cells PubMed
HIV-1 cell-to-cell transmission (Jurkat-to-Jurkat and PBMCs-to-Jurkat) is inhibited by IFITM1 PubMed
HIV-1 cell-to-cell transmission (Jurkat-to-Jurkat) is inhibited by IFITM1 and this inhibition appears to be regulated by the IFITM protein C terminus, is IFITM-species specific and virus-strain specific PubMed

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 interacts with IFITM1 PubMed
Envelope surface glycoprotein gp160, precursor env Replacement of the Env of HIV-1 BH10 with the counterpart of HIV-1 NL4-3 enables HIV-1 BH10 to replicate in IFITM1-expressing cells, whereas inserting the Env of HIV-1 BH10 into HIV-1 NL4-3 reduces virus replication in the presence of IFITM1 PubMed
env HIV-1 NL4-3 Env inhibits IFITM1-mediated restriction of HIV-1 replication by enhancing HIV-1 cell-to-cell transmission PubMed
env Vpu34 (a stop-codon at position 35) and EnvG367E mutations rescue HIV-1 replication in IFITM1-expressing SupT1 cells by enhancing HIV-1 cell-to-cell transmission PubMed
Envelope transmembrane glycoprotein gp41 env HIV-1 gp41 interacts with IFITM1 PubMed
Nef nef IFITM1 significantly downregulates the expression of HIV-1 Nef by interfering with Tat/TAR-mediated expression PubMed
Pr55(Gag) gag IFITM1, IFITM2, and IFITM3 proteins (IFITMs) co-localize with HIV-1 Gag in virus-producing cells and co-assemble with Gag into budding particles PubMed
gag Endogenous IFITM1/2/3 proteins are upregulated in activated CD4+ T cells and incorporated into HIV-1 Gag/p24-associated virions during infection PubMed
gag IFITM1 significantly downregulates the expression of HIV-1 Gag and CA by interfering with both Rev/RRE- and Tat/TAR-mediated expression PubMed
Tat tat HIV-1 Tat upregulates the expression of interferon induced transmembrane protein 1 (IFITM1) in human primary T cells PubMed
Vif vif IFITM1 significantly downregulates the expression of HIV-1 Vif by interfering with both Rev/RRE- and Tat/TAR-mediated expression PubMed
Vpr vpr HIV-1 gp160 interacts with IFITM1 PubMed
vpr HIV-1 Vpr upregulates the expression of IFITM1 in human monocyte-derived dendritic cells PubMed
vpr IFITM1, 2 or 3 marginally inhibit the entry of HIV-1 NL4-3 and SIV Mac into TZM-bl by measuring the cleavage of CCF2 by BlaM-Vpr that enters the cytoplasm together with viral cores PubMed
Vpu vpu Vpu34 (a stop-codon at position 35) and EnvG367E mutations rescue HIV-1 replication in IFITM1-expressing SupT1 cells by enhancing HIV-1 cell-to-cell transmission PubMed
capsid gag IFITM1, IFITM2, and IFITM3 proteins (IFITMs) co-localize with HIV-1 CA in velocity gradients, indicating that IFITMs are virion-associated proteins PubMed
gag Endogenous IFITM1/2/3 proteins are upregulated in activated CD4+ T cells and incorporated into HIV-1 Gag/p24-associated virions during infection PubMed
gag Depletion of IFITM1 expression upregulates HIV-1 CA A92E mutant infectivity in CsA-untreated HeLa cells and downregulates its infectivity in CsA-treated HeLa cells PubMed
gag IFITM1 significantly downregulates the expression of HIV-1 Gag and CA by interfering with both Rev/RRE- and Tat/TAR-mediated expression PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cell surface receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
defense response to virus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of viral entry into host cell IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of viral entry into host cell IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of viral genome replication IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of viral genome replication IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of viral genome replication IMP
Inferred from Mutant Phenotype
more info
PubMed 
ossification IEA
Inferred from Electronic Annotation
more info
 
positive regulation of osteoblast differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of immune response TAS
Traceable Author Statement
more info
 
response to interferon-alpha IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
response to interferon-alpha IDA
Inferred from Direct Assay
more info
PubMed 
response to interferon-beta IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
response to interferon-beta IDA
Inferred from Direct Assay
more info
PubMed 
response to interferon-gamma IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
response to interferon-gamma IDA
Inferred from Direct Assay
more info
PubMed 
response to virus IDA
Inferred from Direct Assay
more info
PubMed 
type I interferon signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
type I interferon signaling pathway TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane HDA PubMed 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
interferon-induced transmembrane protein 1
Names
dispanin subfamily A member 2a
interferon-induced protein 17
interferon-inducible protein 9-27
leu-13 antigen

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003641.5NP_003632.4  interferon-induced transmembrane protein 1

    Status: VALIDATED

    Source sequence(s)
    AC136475
    Consensus CDS
    CCDS41584.1
    Related
    ENSP00000386187.3, ENST00000408968.4

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    314040..315272
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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