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SUR2 sphingosine hydroxylase [ Saccharomyces cerevisiae S288C ]

Gene ID: 851891, updated on 7-Jun-2026
Official Symbol
SUR2
Official Full Name
sphingosine hydroxylase
Primary source
SGD:S000002705
Locus tag
YDR297W
See related
AllianceGenome:SGD:S000002705; FungiDB:YDR297W; VEuPathDB:YDR297W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
SYR2
Summary
Enables sphingolipid C4-monooxygenase activity. Involved in sphingolipid metabolic process. Located in endoplasmic reticulum membrane. Orthologous to human CH25H (cholesterol 25-hydroxylase). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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See SUR2 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (1056551..1057600)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Hda2p Neighboring gene mitochondrial 54S ribosomal protein mL67 MHR1 Neighboring gene F1F0 ATP synthase subunit 5 Neighboring gene rRNA-processing protein BFR2

Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Yeast genes involved in growth inhibition by Pseudomonas syringae pv. syringae syringomycin family lipodepsipeptides. Takemoto JY, et al. FEMS Microbiol Lett, 1993 Dec 15. PMID 8288110
  2. SYR2, a gene necessary for syringomycin growth inhibition of Saccharomyces cerevisiae. Cliften P, et al. Microbiology (Reading), 1996 Mar. PMID 8868422
  3. Syringomycin action gene SYR2 is essential for sphingolipid 4-hydroxylation in Saccharomyces cerevisiae. Grilley MM, et al. J Biol Chem, 1998 May 1. PMID 9556590
  4. Stereochemistry of a bifunctional dihydroceramide delta 4-desaturase/hydroxylase from Candida albicans; a key enzyme of sphingolipid metabolism. Beckmann C, et al. Org Biomol Chem, 2003 Jul 21. PMID 12956060
  5. Identification of fungal sphingolipid C9-methyltransferases by phylogenetic profiling. Ternes P, et al. J Biol Chem, 2006 Mar 3. PMID 16339149

See all (89) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
  
enables sphingolipid C4-monooxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sphingolipid C4-monooxygenase activity IEA
Inferred from Electronic Annotation
more info
  
enables sphingolipid C4-monooxygenase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables sphingolipid C4-monooxygenase activity RCA
inferred from Reviewed Computational Analysis
more info
  
enables sphingolipid delta-4 desaturase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in lipid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in sphingoid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sphingolipid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in sphingolipid biosynthetic process RCA
inferred from Reviewed Computational Analysis
more info
  
involved_in sphingolipid metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytosol RCA
inferred from Reviewed Computational Analysis
more info
  
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
sphingosine hydroxylase
NP_010583.1
  • Sphinganine C4-hydroxylase; catalyses the conversion of sphinganine to phytosphingosine in sphingolipid biosyntheis

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    1056551..1057600
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180605.1 → NP_010583.1  sphingosine hydroxylase

    See identical proteins and their annotated locations for NP_010583.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VSS6, P38992
    UniProtKB/TrEMBL
    B3LFZ8, B5VGH5, C7GQU7, C8Z5K9, G2WB35, N1P8K6
    Conserved Domains (1) summary
    COG3000
    Location:40 → 337
    ERG3; Sterol desaturase/sphingolipid hydroxylase, fatty acid hydroxylase superfamily [Lipid transport and metabolism]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P38992.1

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