SRP101 signal recognition particle receptor subunit alpha [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: SRP101
Official Full Name: signal recognition particle receptor subunit alpha
Primary source: SGD:S000002700
Locus tag: YDR292C
See related: AllianceGenome:SGD:S000002700; FungiDB:YDR292C; VEuPathDB:YDR292C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables signal recognition particle binding activity. Involved in protein targeting to ER. Located in endoplasmic reticulum membrane. Part of signal recognition particle receptor complex. Orthologous to human SRPRA (SRP receptor subunit alpha). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs: all
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Chromosome IV - NC_001136.10 Genomic Context describing neighboring genes

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables signal recognition particle binding	IBA Inferred from Biological aspect of Ancestor more info
enables signal recognition particle binding	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in SRP-dependent cotranslational protein targeting to membrane	IEA Inferred from Electronic Annotation more info
involved_in SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition	NAS Non-traceable Author Statement more info	PubMed
involved_in protein targeting to ER	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein targeting to ER	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	HDA more info	PubMed
located_in endoplasmic reticulum membrane	EXP Inferred from Experiment more info	PubMed
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum membrane	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	NAS Non-traceable Author Statement more info	PubMed
part_of protein-containing complex	IEA Inferred from Electronic Annotation more info
part_of signal recognition particle receptor complex	IPI Inferred from Physical Interaction more info	PubMed

NP_010578.3

Signal recognition particle (SRP) receptor alpha subunit; contain GTPase domains; involved in SRP-dependent protein targeting; interacts with the beta subunit, Srp102p

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