INM2 inositol monophosphate 1-phosphatase INM2 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: INM2
Official Full Name: inositol monophosphate 1-phosphatase INM2
Primary source: SGD:S000002695
Locus tag: YDR287W
See related: AllianceGenome:SGD:S000002695; FungiDB:YDR287W; VEuPathDB:YDR287W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables inositol monophosphate 1-phosphatase activity. Involved in inositol phosphate catabolic process. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 59; bipolar disorder; intellectual disability; and schizophrenia. Orthologous to several human genes including IMPA2 (inositol monophosphatase 2). [provided by Alliance of Genome Resources, Apr 2025]
Orthologs: all
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Genomic context

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See INM2 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 1

Sequence:: Chromosome: IV; NC_001136.10 (1035995..1036873)

Chromosome IV - NC_001136.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables inositol monophosphate 1-phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables inositol monophosphate 1-phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables inositol monophosphate 1-phosphatase activity	IEA Inferred from Electronic Annotation more info
enables inositol monophosphate 1-phosphatase activity	IGI Inferred from Genetic Interaction more info	PubMed
enables inositol monophosphate 1-phosphatase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables inositol monophosphate 1-phosphatase activity	ISA Inferred from Sequence Alignment more info	PubMed
enables inositol monophosphate 1-phosphatase activity	RCA inferred from Reviewed Computational Analysis more info
enables inositol monophosphate phosphatase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in inositol biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in inositol biosynthetic process	RCA inferred from Reviewed Computational Analysis more info
involved_in inositol metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in inositol phosphate catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in inositol phosphate catabolic process	IEA Inferred from Electronic Annotation more info
involved_in inositol phosphate catabolic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in inositol phosphate catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phosphatidylinositol phosphate biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytosol	RCA inferred from Reviewed Computational Analysis more info

General protein information

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Preferred Names: inositol monophosphate 1-phosphatase INM2

NP_010573.3

EC 3.1.3.25

Inositol monophosphatase; involved in biosynthesis of inositol; enzymatic activity requires magnesium ions and is inhibited by lithium and sodium ions; inm1 inm2 double mutant lacks inositol auxotrophy

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001136.10 Reference assembly

Range

1035995..1036873

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001180595.3 → NP_010573.3 inositol monophosphate 1-phosphatase INM2

See identical proteins and their annotated locations for NP_010573.3

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VSR7, Q05533

UniProtKB/TrEMBL

B5VGG3, C7GQT8, C8Z5J9, N1P8J8

Conserved Domains (1) summary

cd01639
Location:13 → 265

IMPase; inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be recycled ...