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GCN2 serine/threonine-protein kinase GCN2 [ Saccharomyces cerevisiae S288C ]

Gene ID: 851877, updated on 2-Nov-2024

Summary

Official Symbol
GCN2
Official Full Name
serine/threonine-protein kinase GCN2
Primary source
SGD:S000002691
Locus tag
YDR283C
See related
AllianceGenome:SGD:S000002691; FungiDB:YDR283C; VEuPathDB:YDR283C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
AAS1; AAS102; NDR2
Summary
Enables eukaryotic translation initiation factor 2alpha kinase activity and tRNA binding activity. Involved in intracellular signal transduction; positive regulation of cellular response to amino acid starvation; and regulation of translational initiation. Is active in cytosolic ribosome. Human ortholog(s) of this gene implicated in pulmonary venoocclusive disease 2. Orthologous to human EIF2AK4 (eukaryotic translation initiation factor 2 alpha kinase 4). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

See GCN2 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (1025070..1030049, complement)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Phm6p Neighboring gene Mrx10p Neighboring gene bifunctional diacylglycerol diphosphate phosphatase/phosphatidate phosphatase Neighboring gene Zip1p

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables eukaryotic translation initiation factor 2alpha kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables eukaryotic translation initiation factor 2alpha kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables eukaryotic translation initiation factor 2alpha kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H2AS1 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables tRNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables tRNA binding IEA
Inferred from Electronic Annotation
more info
 
enables tRNA binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
involved_in DNA damage checkpoint signaling IEA
Inferred from Electronic Annotation
more info
 
involved_in DNA damage checkpoint signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in GCN2-mediated signaling IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to amino acid starvation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of translational initiation in response to stress IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of cellular response to amino acid starvation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of cellular response to amino acid starvation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in post-transcriptional regulation of gene expression IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of protein metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of translation IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of translational initiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of translational initiation by eIF2 alpha phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in translation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in cytosolic ribosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosolic ribosome IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
serine/threonine-protein kinase GCN2
NP_010569.3
  • Protein kinase; phosphorylates the alpha-subunit of translation initiation factor eIF2 (Sui2p) in response to starvation; activated by uncharged tRNAs and the Gcn1p-Gcn20p complex; contributes to DNA damage checkpoint control

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    1025070..1030049 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180591.3NP_010569.3  TPA: serine/threonine-protein kinase GCN2 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010569.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VSR3, P15442
    UniProtKB/TrEMBL
    A6ZYN2, B5VGG1, N1P8J5
    Conserved Domains (5) summary
    smart00591
    Location:18128
    RWD; domain in RING finger and WD repeat containing proteins and DEXDc-like helicases subfamily related to the UBCc domain
    COG0124
    Location:10151485
    HisS; Histidyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]
    cd14012
    Location:273526
    PK_eIF2AK_GCN2_rpt1; Pseudokinase domain, repeat 1, of eukaryotic translation Initiation Factor 2-Alpha Kinase 4 or General Control Non-derepressible-2
    cd14046
    Location:593979
    STKc_EIF2AK4_GCN2_rpt2; Catalytic domain, repeat 2, of the Serine/Threonine kinase, eukaryotic translation Initiation Factor 2-Alpha Kinase 4 or General Control Non-derepressible-2
    pfam12745
    Location:13871657
    HGTP_anticodon2; Anticodon binding domain of tRNAs