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RTN1 Rtn1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 851819, updated on 3-May-2025
Official Symbol
RTN1
Official Full Name
Rtn1p
Primary source
SGD:S000002641
Locus tag
YDR233C
See related
AllianceGenome:SGD:S000002641; FungiDB:YDR233C; VEuPathDB:YDR233C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Involved in several processes, including ER-dependent peroxisome organization; endoplasmic reticulum organization; and nuclear pore complex assembly. Located in Golgi apparatus; cortical endoplasmic reticulum; and endoplasmic reticulum membrane. Orthologous to human RTN4 (reticulon 4). [provided by Alliance of Genome Resources, May 2025]
Orthologs
all
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See RTN1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (929470..930357, complement)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Cox20p Neighboring gene 5-aminolevulinate synthase Neighboring gene homoaconitate hydratase LYS4 Neighboring gene mRNA splicing protein PRP42

Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Vps13 is required for the packaging of the ER into autophagosomes during ER-phagy. Chen S, et al. Proc Natl Acad Sci U S A, 2020 Aug 4. PMID 32690699, Free PMC Article
  2. High-curvature domains of the ER are important for the organization of ER exit sites in Saccharomyces cerevisiae. Okamoto M, et al. J Cell Sci, 2012 Jul 15. PMID 22467862
  3. The reticulon and DP1/Yop1p proteins form immobile oligomers in the tubular endoplasmic reticulum. Shibata Y, et al. J Biol Chem, 2008 Jul 4. PMID 18442980, Free PMC Article
  4. Membrane proteins of the endoplasmic reticulum induce high-curvature tubules. Hu J, et al. Science, 2008 Feb 29. PMID 18309084
  5. Membrane-shaping host reticulon proteins play crucial roles in viral RNA replication compartment formation and function. Diaz A, et al. Proc Natl Acad Sci U S A, 2010 Sep 14. PMID 20805477, Free PMC Article

See all (141) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. two integral membrane peroxins (proteins required for peroxisome biogenesis) in Saccharomyces cerevisiae, Pex29 and Pex30, reside in distinct regions of the ER and associate with Rtn1 and Yop1, reticulon family members that contribute to ER morphology, to govern peroxisome emergence from the ER.
    Title: Peroxins Pex30 and Pex29 Dynamically Associate with Reticulons to Regulate Peroxisome Biogenesis from the Endoplasmic Reticulum.
  2. Rtn1 and Yop1 also physically interacted with Ndc1 and other NPC membrane proteins. We propose that NPC and SPB biogenesis are altered in cells lacking Rtn1 and Yop1 due to competition between these complexes for Ndc1
    Title: Integrity and function of the Saccharomyces cerevisiae spindle pole body depends on connections between the membrane proteins Ndc1, Rtn1, and Yop1.
  3. reveal and dissect the critical roles of the reticulon homology domain proteins (Rtn1p, Rtn2p, and Yop1p) in brome mosaic virus RNA replication compartment formation and function
    Title: Membrane-shaping host reticulon proteins play crucial roles in viral RNA replication compartment formation and function.
  4. In this study, we report that members of the RTN and Yop1/DP1 families are required for nuclear pore formation.
    Title: ER membrane-bending proteins are necessary for de novo nuclear pore formation.
  5. Sbh1p co-precipitates with the ER transmembrane protein Rtn1p. Sbh1p-Rtn1p complexes do not appear to contain Sss1p and Sec61p.
    Title: The transmembrane domain is sufficient for Sbh1p function, its association with the Sec61 complex, and interaction with Rtn1p.
  6. The interaction of Rtn1p with the exocyst at the bud tip may trigger the formation of a cortical ER network in yeast buds.
    Title: Rtn1p is involved in structuring the cortical endoplasmic reticulum.
  7. The Rtn1 protein is localized predominantly to the endoplasmic reticulum and secondarily to the Golgi.
    Title: Saccharomyces cerevisiae Rab-GDI displacement factor ortholog Yip3p forms distinct complexes with the Ypt1 Rab GTPase and the reticulon Rtn1p.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in ER-dependent peroxisome organization IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in endoplasmic reticulum inheritance IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in endoplasmic reticulum tubular network maintenance IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in endoplasmic reticulum tubular network organization IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in endoplasmic reticulum tubular network organization IPI
Inferred from Physical Interaction
more info
 PubMed 
involved_in nuclear pore complex assembly IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within response to bacterium IEA
Inferred from Electronic Annotation
more info
  
involved_in response to endoplasmic reticulum stress IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell periphery HDA PubMed 
located_in cortical endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum HDA PubMed 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum tubular network IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
Preferred Names
Rtn1p
NP_010519.3
  • Reticulon protein; involved in nuclear pore assembly and maintenance of tubular ER morphology; promotes membrane curvature; regulates the ER asymmetry-induced inheritance block during ER stress; role in ER-derived peroxisomal biogenesis; increases tubular ER when overexpressed; mutants have reduced phosphatidylserine transfer between the ER and mitochondria; interacts with exocyst subunit Sec6p, Yip3p, and Sbh1p; member of the RTNLA subfamily

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    929470..930357 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180541.3 → NP_010519.3  TPA: Rtn1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010519.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VSL4, Q04947
    UniProtKB/TrEMBL
    G2WAX7, N1P514
    Conserved Domains (1) summary
    pfam02453
    Location:21 → 178
    Reticulon
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q04947.1

Gene LinkOut

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