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RAD9 chromatin-binding protein RAD9 [ Saccharomyces cerevisiae S288C ]

Gene ID: 851803, updated on 7-Oct-2018

Summary

Gene symbol
RAD9
Gene description
chromatin-binding protein RAD9
Primary source
SGD:S000002625
Locus tag
YDR217C
Gene type
protein coding
RNA name
chromatin-binding protein RAD9
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces

Genomic context

See RAD9 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (899551..903480, complement)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene hypothetical protein Neighboring gene DNA-binding transcription factor ADR1 Neighboring gene septin SPR28 Neighboring gene Mfb1p

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Cell Cycle and Cell Division, organism-specific biosystem (from WikiPathways)
    Cell Cycle and Cell Division, organism-specific biosystem(From http://en.wikipedia.org/wiki/Cell_cycle) The cell cycle is the series of events that takes place in a cell leading to its division and duplication (replication). Regulation of the cell cycle in...
  • Cell cycle - yeast, organism-specific biosystem (from KEGG)
    Cell cycle - yeast, organism-specific biosystemMitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps (G1 and G2 phases). G1, S, and G...
  • Cell cycle - yeast, conserved biosystem (from KEGG)
    Cell cycle - yeast, conserved biosystemMitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps (G1 and G2 phases). G1, S, and G...
  • Meiosis - yeast, organism-specific biosystem (from KEGG)
    Meiosis - yeast, organism-specific biosystemDuring meiosis, a single round of DNA replication is followed by two rounds of chromosome segregation, called meiosis I and meiosis II. At meiosis I, one pair of sister chromatids recombines with, th...
  • Meiosis - yeast, conserved biosystem (from KEGG)
    Meiosis - yeast, conserved biosystemDuring meiosis, a single round of DNA replication is followed by two rounds of chromosome segregation, called meiosis I and meiosis II. At meiosis I, one pair of sister chromatids recombines with, th...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by GO

Function Evidence Code Pubs
double-stranded DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enzyme activator activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
histone binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
histone binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
DNA damage checkpoint IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA damage checkpoint IMP
Inferred from Mutant Phenotype
more info
PubMed 
DNA repair IGI
Inferred from Genetic Interaction
more info
PubMed 
DNA repair IMP
Inferred from Mutant Phenotype
more info
PubMed 
G1 DNA damage checkpoint IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell cycle IEA
Inferred from Electronic Annotation
more info
 
cellular response to DNA damage stimulus IEA
Inferred from Electronic Annotation
more info
 
double-strand break repair IMP
Inferred from Mutant Phenotype
more info
PubMed 
intra-S DNA damage checkpoint IMP
Inferred from Mutant Phenotype
more info
PubMed 
mitotic G1 DNA damage checkpoint IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of DNA replication IEA
Inferred from Electronic Annotation
more info
 
nucleotide-excision repair IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of catalytic activity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of cell cycle IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
chromatin IDA
Inferred from Direct Assay
more info
PubMed 
chromatin IMP
Inferred from Mutant Phenotype
more info
PubMed 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IC
Inferred by Curator
more info
PubMed 
nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
chromatin-binding protein RAD9
NP_010503.1
  • DNA damage-dependent checkpoint protein; required for cell-cycle arrest in G1/S, intra-S, and G2/M, plays a role in postreplication repair (PRR) pathway; transmits checkpoint signal by activating Rad53p and Chk1p; hyperphosphorylated by Mec1p and Tel1p; multiple cyclin dependent kinase consensus sites and the C-terminal BRCT domain contribute to DNA damage checkpoint activation; Rad9p Chk1 Activating Domain (CAD) is phosphorylated at multiple sites by Cdc28p/Clb2p

NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    899551..903480 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180525.1NP_010503.1  TPA: chromatin-binding protein RAD9 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010503.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P14737
    Conserved Domains (2) summary
    pfam08605
    Location:772900
    Rad9_Rad53_bind; Fungal Rad9-like Rad53-binding
    pfam00533
    Location:9971109
    BRCT; BRCA1 C Terminus (BRCT) domain
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