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TCP1 chaperonin-containing T-complex alpha subunit TCP1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 851798, updated on 5-Aug-2018

Summary

Gene symbol
TCP1
Gene description
chaperonin-containing T-complex alpha subunit TCP1
Primary source
SGD:S000002620
Locus tag
YDR212W
Gene type
protein coding
RNA name
chaperonin-containing T-complex alpha subunit TCP1
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
CCT1

Genomic context

See TCP1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (887232..888911)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene tRNA Neighboring gene translation initiation factor eIF2B catalytic subunit epsilon Neighboring gene Upc2p Neighboring gene Aha1p

Bibliography

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GO

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
unfolded protein binding IDA
Inferred from Direct Assay
more info
PubMed 
unfolded protein binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
protein folding IDA
Inferred from Direct Assay
more info
PubMed 
protein folding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
chaperonin-containing T-complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chaperonin-containing T-complex IDA
Inferred from Direct Assay
more info
PubMed 
chaperonin-containing T-complex IPI
Inferred from Physical Interaction
more info
PubMed 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
plasma membrane HDA PubMed 

General protein information

Preferred Names
chaperonin-containing T-complex alpha subunit TCP1
NP_010498.1
  • Alpha subunit of chaperonin-containing T-complex; complex mediates protein folding in the cytosol; involved in actin cytoskeleton maintenance; overexpression in neurons suppresses formation of pathogenic conformations of huntingtin protein

NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    887232..888911
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180520.1NP_010498.1  TPA: chaperonin-containing T-complex alpha subunit TCP1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010498.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P12612
    Conserved Domains (1) summary
    cd03335
    Location:17549
    TCP1_alpha; TCP-1 (CTT or eukaryotic type II) chaperonin family, alpha subunit. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings. In contrast to bacterial group I chaperonins ...
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