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CAB5 putative dephospho-CoA kinase [ Saccharomyces cerevisiae S288C ]

Gene ID: 851777, updated on 9-Dec-2024

Summary

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Official Symbol
CAB5
Official Full Name
putative dephospho-CoA kinase
Primary source
SGD:S000002604
Locus tag
YDR196C
See related
AllianceGenome:SGD:S000002604; FungiDB:YDR196C; VEuPathDB:YDR196C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to enable dephospho-CoA kinase activity. Involved in coenzyme A biosynthetic process. Located in lipid droplet. Is extrinsic component of mitochondrial outer membrane. Part of CoA-synthesizing protein complex. Used to study neurodegeneration with brain iron accumulation 6. Orthologous to human DCAKD (dephospho-CoA kinase domain containing). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See CAB5 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (850274..850999, complement)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene RNA-processing protein REF2 Neighboring gene Cbs2p Neighboring gene protein-lysine N-methyltransferase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Modeling human Coenzyme A synthase mutation in yeast reveals altered mitochondrial function, lipid content and iron metabolism. Ceccatelli Berti C, et al. Microb Cell, 2015 Apr 6. PMID 28357284, Free PMC Article
  2. Molecular characterization of the heteromeric coenzyme A-synthesizing protein complex (CoA-SPC) in the yeast Saccharomyces cerevisiae. Olzhausen J, et al. FEMS Yeast Res, 2013 Sep. PMID 23789928
  3. Genetic analysis of coenzyme A biosynthesis in the yeast Saccharomyces cerevisiae: identification of a conditional mutation in the pantothenate kinase gene CAB1. Olzhausen J, et al. Curr Genet, 2009 Apr. PMID 19266201
  4. Increased biosynthesis of acetyl-CoA in the yeast Saccharomyces cerevisiae by overexpression of a deregulated pantothenate kinase gene and engineering of the coenzyme A biosynthetic pathway. Olzhausen J, et al. Appl Microbiol Biotechnol, 2021 Oct. PMID 34491400, Free PMC Article
  5. Complete reconstitution of the human coenzyme A biosynthetic pathway via comparative genomics. Daugherty M, et al. J Biol Chem, 2002 Jun 14. PMID 11923312

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables dephospho-CoA kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables dephospho-CoA kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables dephospho-CoA kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in coenzyme A biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in coenzyme A biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in coenzyme A biosynthetic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
part_of CoA-synthesizing protein complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol HDA PubMed 
located_in endoplasmic reticulum HDA PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in extrinsic component of mitochondrial outer membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in lipid droplet IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion HDA PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear envelope HDA PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
putative dephospho-CoA kinase
NP_010482.3
  • Subunit of the CoA-Synthesizing Protein Complex (CoA-SPC); subunits of this complex are: Cab2p, Cab3p, Cab4p, Cab5p, Sis2p and Vhs3p; probable dephospho-CoA kinase (DPCK) that catalyzes the last step in coenzyme A biosynthesis; involved in histone acylation; null mutant lethality is complemented by human homologs DCAKD and COASY and by E. coli coaE (encoding DPCK); extrinsic component of the mitochondrial outer membrane that also localizes to lipid droplets

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    850274..850999 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180504.3 → NP_010482.3  TPA: putative dephospho-CoA kinase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010482.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VSH9, Q03941
    UniProtKB/TrEMBL
    A6ZYF5, B3LG87, B5VG89, C7GN01, C8Z5B1, N1P4X9
    Conserved Domains (1) summary
    pfam01121
    Location:2 → 188
    CoaE; Dephospho-CoA kinase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q03941.1

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