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HST4 NAD-dependent histone deacetylase HST4 [ Saccharomyces cerevisiae S288C ]

Gene ID: 851772, updated on 9-Sep-2018

Summary

Gene symbol
HST4
Gene description
NAD-dependent histone deacetylase HST4
Primary source
SGD:S000002599
Locus tag
YDR191W
Gene type
protein coding
RNA name
NAD-dependent histone deacetylase HST4
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces

Genomic context

See HST4 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (842337..843449)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene syntaxin-binding protein Neighboring gene RuvB family ATP-dependent DNA helicase pontin Neighboring gene FG-nucleoporin NUP42 Neighboring gene ATP-dependent RNA helicase

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GO

Function Evidence Code Pubs
NAD+ binding IEA
Inferred from Electronic Annotation
more info
 
NAD-dependent histone deacetylase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
NAD-dependent histone deacetylase activity IDA
Inferred from Direct Assay
more info
PubMed 
hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
cellular response to DNA damage stimulus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to biotin starvation IMP
Inferred from Mutant Phenotype
more info
PubMed 
chromatin silencing at centromere IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chromatin silencing at telomere IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chromatin silencing at telomere IGI
Inferred from Genetic Interaction
more info
PubMed 
histone H3-K56 deacetylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
histone H4-K12 deacetylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
histone H4-K16 deacetylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
histone deacetylation IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
pericentric heterochromatin assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of DNA repair IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of nucleosome density IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
replication-born double-strand break repair via sister chromatid exchange IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
replication-born double-strand break repair via sister chromatid exchange IMP
Inferred from Mutant Phenotype
more info
PubMed 
short-chain fatty acid metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
chromosome, telomeric region IEA
Inferred from Electronic Annotation
more info
 
cytoplasm HDA PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
mating-type region heterochromatin IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
nuclear pericentric heterochromatin IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear rDNA heterochromatin IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear subtelomeric heterochromatin IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus HDA PubMed 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
NAD-dependent histone deacetylase HST4
NP_010477.3
  • NAD(+)-dependent protein deacetylase; deacetylation targets are primarily mitochondrial proteins; involved along with Hst3p in silencing at telomeres, cell cycle progression, radiation resistance, genomic stability and short-chain fatty acid metabolism; accumulates in mitochondria in response to biotin starvation and may link biotin metabolism with energy homeostasis; member of the Sir2 family and may be the functional equivalent of human SIRT3

NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    842337..843449
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180499.3NP_010477.3  TPA: NAD-dependent histone deacetylase HST4 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010477.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P53688
    Conserved Domains (1) summary
    COG0846
    Location:77370
    SIR2; NAD-dependent protein deacetylase, SIR2 family [Posttranslational modification, protein turnover, chaperones]
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