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SAS4 Sas4p [ Saccharomyces cerevisiae S288C ]

Gene ID: 851762, updated on 3-May-2025
Official Symbol
SAS4
Official Full Name
Sas4p
Primary source
SGD:S000002589
Locus tag
YDR181C
See related
AllianceGenome:SGD:S000002589; FungiDB:YDR181C; VEuPathDB:YDR181C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables histone acetyltransferase activity. Involved in subtelomeric heterochromatin formation. Located in chromatin. Part of SAS acetyltransferase complex. [provided by Alliance of Genome Resources, May 2025]
Orthologs
all
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See SAS4 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (825910..827355, complement)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Nvj3p Neighboring gene cohesin-loading factor complex subunit SCC2 Neighboring gene putative lipid phosphatase CDC1 Neighboring gene uncharacterized protein

Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Sas4 and Sas5 are required for the histone acetyltransferase activity of Sas2 in the SAS complex. Sutton A, et al. J Biol Chem, 2003 May 9. PMID 12626510
  2. Identification of SAS4 and SAS5, two genes that regulate silencing in Saccharomyces cerevisiae. Xu EY, et al. Genetics, 1999 Sep. PMID 10471696, Free PMC Article
  3. SAS4 and SAS5 are locus-specific regulators of silencing in Saccharomyces cerevisiae. Xu EY, et al. Genetics, 1999 Sep. PMID 10471697, Free PMC Article
  4. Positive roles of SAS2 in DNA replication and transcriptional silencing in yeast. Zou Y, et al. Nucleic Acids Res, 2008 Sep. PMID 18682530, Free PMC Article
  5. Proliferating cell nuclear antigen (PCNA) is required for cell cycle-regulated silent chromatin on replicated and nonreplicated genes. Miller A, et al. J Biol Chem, 2010 Nov 5. PMID 20813847, Free PMC Article

See all (41) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables acetyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables histone acetyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone acetyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within chromatin organization IEA
Inferred from Electronic Annotation
more info
  
involved_in subtelomeric heterochromatin formation IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of SAS acetyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of SAS acetyltransferase complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of SAS acetyltransferase complex IEA
Inferred from Electronic Annotation
more info
  
located_in chromatin IDA
Inferred from Direct Assay
more info
 PubMed 
located_in chromosome, telomeric region IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
Sas4p
NP_010467.1
  • Subunit of the SAS complex (Sas2p, Sas4p, Sas5p); acetylates free histones and nucleosomes and regulates transcriptional silencing; required for the HAT activity of Sas2p

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    825910..827355 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180489.1 → NP_010467.1  TPA: Sas4p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010467.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VSG4, Q04003
    UniProtKB/TrEMBL
    B3LGA1, B5VG75, C8Z595
    Conserved Domains (1) summary
    pfam15460
    Location:124 → 222
    SAS4; Something about silencing, SAS, complex subunit 4
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q04003.1

Gene LinkOut

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