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HMO1 Hmo1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 851754, updated on 8-Sep-2022

Summary

Gene symbol
HMO1
Gene description
Hmo1p
Primary source
SGD:S000002581
Locus tag
YDR174W
See related
AllianceGenome:SGD:S000002581
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
HSM2
Summary
Enables DNA binding activity, bending; double-stranded DNA binding activity; and four-way junction DNA binding activity. Involved in several processes, including chromosome organization; regulation of transcription, DNA-templated; and transcriptional start site selection at RNA polymerase II promoter. Located in cytosol; nucleolus; and rDNA heterochromatin. Part of small-subunit processome. Colocalizes with chromatin. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

See HMO1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (812110..812850)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene translation termination factor GTPase eRF3 Neighboring gene inositol polyphosphate multikinase Neighboring gene mitochondrial 37S ribosomal protein RSM24 Neighboring gene histone acetyltransferase NGG1

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GO

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA binding, bending IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables DNA binding, bending IDA
Inferred from Direct Assay
more info
PubMed 
enables double-stranded DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables four-way junction DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein-containing complex binding IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
colocalizes_with chromatin IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
located_in rDNA heterochromatin IDA
Inferred from Direct Assay
more info
PubMed 
part_of small-subunit processome IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
Hmo1p
NP_010459.1
  • Chromatin associated high mobility group (HMG) family member; involved in compacting, bending, bridging and looping DNA; rDNA-binding component that regulates transcription from RNA polymerase I promoters; regulates start site selection of ribosomal protein genes via RNA polymerase II promoters; role in genome maintenance; associates with a 5'-3' DNA helicase and Fpr1p, a prolyl isomerase; relocalizes to the cytosol in response to hypoxia

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    812110..812850
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180481.1NP_010459.1  TPA: Hmo1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010459.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VSF6, Q03973
    UniProtKB/TrEMBL
    A0A0L8VTF5, A0A6C1DPA6, A0A6L0YYN5, A0A815XHP8, A6ZYD2, B3LGA9, G2WAS2
    Conserved Domains (1) summary
    COG5648
    Location:36246
    NHP6B; Chromatin-associated proteins containing the HMG domain [Chromatin structure and dynamics]