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ARG82 inositol polyphosphate multikinase [ Saccharomyces cerevisiae S288C ]

Gene ID: 851753, updated on 18-Jan-2023

Summary

Gene symbol
ARG82
Gene description
inositol polyphosphate multikinase
Primary source
SGD:S000002580
Locus tag
YDR173C
See related
AllianceGenome:SGD:S000002580
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
ARGR3; IPK2
Summary
Enables kinase activity and protein-macromolecule adaptor activity. Involved in several processes, including organophosphate biosynthetic process; protein stabilization; and regulation of transcription by RNA polymerase II. Located in nucleus. Orthologous to human IP6K1 (inositol hexakisphosphate kinase 1); IP6K2 (inositol hexakisphosphate kinase 2); and IP6K3 (inositol hexakisphosphate kinase 3). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

See ARG82 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (810565..811632, complement)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene heat shock protein HSP42 Neighboring gene translation termination factor GTPase eRF3 Neighboring gene Hmo1p Neighboring gene mitochondrial 37S ribosomal protein RSM24

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GO

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables inositol hexakisphosphate kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables inositol tetrakisphosphate 3-kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables inositol tetrakisphosphate 3-kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables inositol tetrakisphosphate 6-kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables inositol-1,3,4,5,6-pentakisphosphate kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables inositol-1,4,5-trisphosphate 3-kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables inositol-1,4,5-trisphosphate 3-kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables inositol-1,4,5-trisphosphate 3-kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables inositol-1,4,5-trisphosphate 6-kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables inositol-1,4,5-trisphosphate 6-kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables phosphatidylinositol 3-kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein-macromolecule adaptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables protein-macromolecule adaptor activity IPI
Inferred from Physical Interaction
more info
PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
inositol polyphosphate multikinase
NP_010458.3
  • Inositol polyphosphate multikinase (IPMK); sequentially phosphorylates Ins(1,4,5)P3 to form Ins(1,3,4,5,6)P5; also has diphosphoinositol polyphosphate synthase activity; regulates genes responsive to arginine, phosphate, and nitrogen; needed by most [PSI+] variants for prion propagation

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    810565..811632 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180480.3NP_010458.3  TPA: inositol polyphosphate multikinase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010458.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    E9P8S7, P07250
    UniProtKB/TrEMBL
    A0A0L8VT81, A0A8H8UN81, B3LGB0, C7GN24
    Conserved Domains (1) summary
    pfam03770
    Location:114352
    IPK; Inositol polyphosphate kinase