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SUP35 translation termination factor GTPase eRF3 [ Saccharomyces cerevisiae S288C ]

Gene ID: 851752, updated on 18-Jan-2023

Summary

Gene symbol
SUP35
Gene description
translation termination factor GTPase eRF3
Primary source
SGD:S000002579
Locus tag
YDR172W
See related
AllianceGenome:SGD:S000002579
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
GST1; PNM2; SAL3; SUF12; SUP2; SUP36
Summary
Enables ribosome binding activity and translation release factor activity. Involved in nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay and translational termination. Located in cytoplasmic stress granule. Part of translation release factor complex. Orthologous to several human genes including GSPT1 (G1 to S phase transition 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

See SUP35 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (808324..810381)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene gag protein Neighboring gene heat shock protein HSP42 Neighboring gene inositol polyphosphate multikinase Neighboring gene Hmo1p

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

  • Homologs of the SUP35 gene: The SUP35 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, A.thaliana, rice, and frog.
  • Orthologs

Gene Ontology Provided by GO

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
 
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
 
enables mRNA binding HDA PubMed 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables ribosome binding IDA
Inferred from Direct Assay
more info
PubMed 
enables translation release factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables translation release factor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables translation release factor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IEA
Inferred from Electronic Annotation
more info
 
involved_in nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of translation IEA
Inferred from Electronic Annotation
more info
 
involved_in translation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in translation IEA
Inferred from Electronic Annotation
more info
 
involved_in translational termination IDA
Inferred from Direct Assay
more info
PubMed 
involved_in translational termination IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasmic stress granule IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol HDA PubMed 
part_of translation release factor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of translation release factor complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
translation termination factor GTPase eRF3
NP_010457.3
  • Translation termination factor eRF3; has a role in mRNA deadenylation and decay; altered protein conformation creates the [PSI(+)] prion that modifies cellular fitness, alters translational fidelity by affecting reading frame selection, and results in a nonsense suppressor phenotype; many stress-response genes are repressed in the presence of [PSI(+)]

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    808324..810381
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180479.3NP_010457.3  TPA: translation termination factor GTPase eRF3 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010457.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P05420, P05453
    UniProtKB/TrEMBL
    H9BH29
    Conserved Domains (2) summary
    COG5256
    Location:254685
    TEF1; Translation elongation factor EF-1alpha (GTPase) [Translation, ribosomal structure and biogenesis]
    PRK10263
    Location:30199
    PRK10263; DNA translocase FtsK; Provisional