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SEC7 Arf family guanine nucleotide exchange factor SEC7 [ Saccharomyces cerevisiae S288C ]

Gene ID: 851748, updated on 4-Feb-2024

Summary

Gene symbol
SEC7
Gene description
Arf family guanine nucleotide exchange factor SEC7
Primary source
SGD:S000002577
Locus tag
YDR170C
See related
AllianceGenome:SGD:S000002577
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables guanyl-nucleotide exchange factor activity. Involved in autophagosome assembly; endoplasmic reticulum to Golgi vesicle-mediated transport; and intra-Golgi vesicle-mediated transport. Located in cytoplasmic vesicle; cytosol; and trans-Golgi network. Human ortholog(s) of this gene implicated in periventricular nodular heterotopia. Orthologous to human ARFGEF1 (ADP ribosylation factor guanine nucleotide exchange factor 1) and ARFGEF2 (ADP ribosylation factor guanine nucleotide exchange factor 2). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

See SEC7 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (796193..802222, complement)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Stb3p Neighboring gene uncharacterized protein Neighboring gene tRNA-Gln Neighboring gene gag protein

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General protein information

Preferred Names
Arf family guanine nucleotide exchange factor SEC7
NP_010454.3
  • Guanine nucleotide exchange factor (GEF) for ADP ribosylation factors; involved in proliferation of the Golgi, intra-Golgi transport and ER-to-Golgi transport; found in the cytoplasm and on Golgi-associated coated vesicles

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    796193..802222 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180477.3NP_010454.3  TPA: Arf family guanine nucleotide exchange factor SEC7 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010454.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VSF1, P11075, Q03960, Q04139
    UniProtKB/TrEMBL
    A0A8H8UN77, A6ZYC8
    Conserved Domains (2) summary
    COG5307
    Location:5041693
    COG5307; Guanine-nucleotide exchange factor, contains Sec7 domain [General function prediction only]
    pfam16213
    Location:283426
    DCB; dimerization and cyclophilin-binding domain of Mon2