SSY1 Ssy1p [Saccharomyces cerevisiae S288C] - Gene

Summary

Go to the top of the page Help

Official Symbol: SSY1
Official Full Name: Ssy1p
Primary source: SGD:S000002567
Locus tag: YDR160W
See related: AllianceGenome:SGD:S000002567; FungiDB:YDR160W; VEuPathDB:YDR160W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: RAA1; SHR10
Summary: Predicted to enable amino acid transmembrane transporter activity. Involved in response to amino acid. Located in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Orthologs: all
: Try the new Gene page
Try the new Transcripts and proteins table

Genomic context

Go to the top of the page Help

See SSY1 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 1

Sequence:: Chromosome: IV; NC_001136.10 (776163..778721)

Chromosome IV - NC_001136.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:: NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Hypersensitive SSY1 mutations negatively influence transition to quiescence in yeast Saccharomyces cerevisiae.
Title: Hypersensitive SSY1 mutations negatively influence transition to quiescence in yeast Saccharomyces cerevisiae.
The Saccharomyces cerevisiae Ssy5 signaling protease (SSY5) is a core component of the plasma membrane (PM)-localized Ssy1-Ptr3-Ssy5 (SPS) sensor.
Title: Spatial and temporal regulation of the endoproteolytic activity of the SPS-sensor-controlled Ssy5 signaling protease.
C-terminal of Ssy1 carries a functional ER-export motif required for proper localization of Ssy1 to the plasma membrane. Ssy1 functions as the primary amino acid receptor and that it carries out this function at the PM.
Title: Ssy1 functions at the plasma membrane as a receptor of extracellular amino acids independent of plasma membrane-endoplasmic reticulum junctions.
Ssy1 localization depends on the presence of a PM-binding domain, an intrinsically disordered linker region of sufficient length.
Title: Intrinsically disordered linker and plasma membrane-binding motif sort Ist2 and Ssy1 to junctions.
Reduced Ssy1-Ptr3-Ssy5 (SPS) signaling extends replicative life span by enhancing NAD+ homeostasis in Saccharomyces cerevisiae.
Title: Reduced Ssy1-Ptr3-Ssy5 (SPS) signaling extends replicative life span by enhancing NAD+ homeostasis in Saccharomyces cerevisiae.
Differential regulation of transcription factors Stp1 and Stp2 in the Ssy1-Ptr3-Ssy5 amino acid sensing pathway.
Title: Differential regulation of transcription factors Stp1 and Stp2 in the Ssy1-Ptr3-Ssy5 amino acid sensing pathway.
SSY1 mutants that constitutively activate a target promoter, were isolated.
Title: Hyper- and hyporesponsive mutant forms of the Saccharomyces cerevisiae Ssy1 amino acid sensor.
Data confirm that a frameshift mutation in a mononucleotide run of eight consecutive T's in the coding region SSY1 causes dramatic differences in gene-expression levels of key genes involved in amino acid biosynthesis.
Title: Cascading transcriptional effects of a naturally occurring frameshift mutation in Saccharomyces cerevisiae.
SSY1, a tranporter-like sensor, allows the cell to respond to changes in nutrient availability through detection of the relative concentrations of intra- and extracellular ligand.
Title: Competitive intra- and extracellular nutrient sensing by the transporter homologue Ssy1p.

Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables amino acid transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in amino acid transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in amino acid transport	IEA Inferred from Electronic Annotation more info
involved_in response to amino acid	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	HDA more info	PubMed
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: Ssy1p

NP_010444.1

Component of the SPS plasma membrane amino acid sensor system; senses external amino acid concentration and transmits intracellular signals that result in regulation of expression of amino acid permease genes; other members are Ssy1p, Ptr3p, and Ssy5p