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RPA14 DNA-directed RNA polymerase I subunit RPA14 [ Saccharomyces cerevisiae S288C ]

Gene ID: 851734, updated on 10-Feb-2026
Official Symbol
RPA14
Official Full Name
DNA-directed RNA polymerase I subunit RPA14
Primary source
SGD:S000002563
Locus tag
YDR156W
See related
AllianceGenome:SGD:S000002563; FungiDB:YDR156W; VEuPathDB:YDR156W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Contributes to DNA-directed RNA polymerase activity. Involved in nucleolar large rRNA transcription by RNA polymerase I. Part of RNA polymerase I complex. [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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See RPA14 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (769525..769938)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Ent5p Neighboring gene peptidylprolyl isomerase CPR1 Neighboring gene uncharacterized protein Neighboring gene aspartate-semialdehyde dehydrogenase Neighboring gene Sac3p

Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. The association of three subunits with yeast RNA polymerase is stabilized by A14. Smid A, et al. J Biol Chem, 1995 Jun 2. PMID 7768955
  2. Crystallization of RNA polymerase I subcomplex A14/A43 by iterative prediction, probing and removal of flexible regions. Geiger SR, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2008 May 1. PMID 18453714, Free PMC Article
  3. Structural and functional homology between the RNAP(I) subunits A14/A43 and the archaeal RNAP subunits E/F. Meka H, et al. Nucleic Acids Res, 2003 Aug 1. PMID 12888498, Free PMC Article
  4. The A14-A43 heterodimer subunit in yeast RNA pol I and their relationship to Rpb4-Rpb7 pol II subunits. Peyroche G, et al. Proc Natl Acad Sci U S A, 2002 Nov 12. PMID 12407181, Free PMC Article
  5. Generation of Fluorescent Versions of Saccharomyces cerevisiae RPA to Study the Conformational Dynamics of Its ssDNA-Binding Domains. Kuppa S, et al. Methods Mol Biol, 2021. PMID 33847957, Free PMC Article

See all (89) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
contributes_to DNA-directed RNA polymerase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-directed RNA polymerase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in nucleolar large rRNA transcription by RNA polymerase I IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in nucleolar large rRNA transcription by RNA polymerase I IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in nucleolar large rRNA transcription by RNA polymerase I IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of cell size HMP PubMed 
involved_in ribosome biogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in termination of RNA polymerase I transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in transcription by RNA polymerase I IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in transcription elongation by RNA polymerase I IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in transcription initiation at RNA polymerase I promoter IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of DNA-directed RNA polymerase complex IEA
Inferred from Electronic Annotation
more info
  
part_of RNA polymerase I complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
Preferred Names
DNA-directed RNA polymerase I subunit RPA14
NP_010440.1
  • RNA polymerase I subunit A14

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    769525..769938
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180463.1 → NP_010440.1  DNA-directed RNA polymerase I subunit RPA14

    See identical proteins and their annotated locations for NP_010440.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VSD7, P50106
    UniProtKB/TrEMBL
    A6ZYB5, B3LGC7, C7GX37, C8Z571, G2WAQ5, N1PAE4
    Conserved Domains (1) summary
    pfam08203
    Location:18 → 102
    RNA_polI_A14; Yeast RNA polymerase I subunit RPA14
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P50106.1

Gene LinkOut

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