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TAF12 Taf12p [ Saccharomyces cerevisiae S288C ]

Gene ID: 851723, updated on 8-Nov-2020

Summary

Gene symbol
TAF12
Gene description
Taf12p
Primary source
SGD:S000002552
Locus tag
YDR145W
Gene type
protein coding
RNA name
Taf12p
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
TAF61; TAF68

Genomic context

See TAF12 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (746738..748357)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene ubiquitin-protein ligase SAN1 Neighboring gene aspartyl protease Neighboring gene DNA-binding transcription factor SWI5 Neighboring gene bifunctional choline kinase/ethanolamine kinase EKI1

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GO

Function Evidence Code Pubs
DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
RNA polymerase II activating transcription factor binding IDA
Inferred from Direct Assay
more info
PubMed 
RNA polymerase II activating transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
contributes_to RNA polymerase II general transcription initiation factor activity IC
Inferred by Curator
more info
 
TBP-class protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
TBP-class protein binding IDA
Inferred from Direct Assay
more info
PubMed 
chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
molecular adaptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
DNA-templated transcription, initiation IEA
Inferred from Electronic Annotation
more info
 
RNA polymerase II preinitiation complex assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
RNA polymerase II preinitiation complex assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
chromatin organization IDA
Inferred from Direct Assay
more info
PubMed 
chromatin organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
histone acetylation IDA
Inferred from Direct Assay
more info
PubMed 
transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
SAGA complex IDA
Inferred from Direct Assay
more info
PubMed 
SAGA complex IEA
Inferred from Electronic Annotation
more info
 
SLIK (SAGA-like) complex IDA
Inferred from Direct Assay
more info
PubMed 
SLIK (SAGA-like) complex IEA
Inferred from Electronic Annotation
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 
transcription factor TFIID complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcription factor TFIID complex IDA
Inferred from Direct Assay
more info
PubMed 
transcription factor TFIID complex IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
Taf12p
NP_010429.1
  • Subunit (61/68 kDa) of TFIID and SAGA complexes; involved in RNA polymerase II transcription initiation and in chromatin modification, similar to histone H2A; overexpression of the human ortholog, TAF12, an oncogene involved in the formation of choroid plexus carcinomas, results in dosage chromosomal instability (dCIN) in a human cell line similar to the dCIN observed in yeast overexpressors

NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    746738..748357
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180452.1NP_010429.1  TPA: Taf12p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010429.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q03761
    Conserved Domains (1) summary
    COG5624
    Location:1539
    COG5624; Transcription initiation factor TFIID, subunit TAF12 [Transcription]
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