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RGP1 Rgp1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 851714, updated on 19-Nov-2025
Official Symbol
RGP1
Official Full Name
Rgp1p
Primary source
SGD:S000002544
Locus tag
YDR137W
See related
AllianceGenome:SGD:S000002544; FungiDB:YDR137W; VEuPathDB:YDR137W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Contributes to guanyl-nucleotide exchange factor activity. Involved in retrograde transport, endosome to Golgi. Located in Golgi membrane. Part of Ric1-Rgp1 guanyl-nucleotide exchange factor complex. Orthologous to human RGP1 (RGP1 homolog, RAB6A GEF complex partner 1). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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See RGP1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (728259..730250)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene ATP-binding cassette glutathione S-conjugate transporter YCF1 Neighboring gene Hpr1p Neighboring gene NEDD8 family protein RUB1

Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Structural basis for Rab6 activation by the Ric1-Rgp1 complex. Feathers JR, et al. Nat Commun, 2024 Dec 4. PMID 39632878, Free PMC Article
  2. Identification of Rgp1p, a novel Golgi recycling factor, as a protein required for efficient localization of yeast casein kinase 1 to the plasma membrane. Panek HR, et al. J Cell Sci, 2000 Dec. PMID 11082047
  3. Ric1p and Rgp1p form a complex that catalyses nucleotide exchange on Ypt6p. Siniossoglou S, et al. EMBO J, 2000 Sep 15. PMID 10990452, Free PMC Article
  4. Decreased aluminium tolerance in the growth of Saccharomyces cerevisiae with SSO2 gene disruption. Yamamoto T, et al. Biometals, 2018 Apr. PMID 29383568
  5. Opposite roles of the F-box protein Rcy1p and the GTPase-activating protein Gyp2p during recycling of internalized proteins in yeast. Lafourcade C, et al. Genetics, 2003 Jun. PMID 12807768, Free PMC Article

See all (62) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
contributes_to guanyl-nucleotide exchange factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
  
contributes_to guanyl-nucleotide exchange factor activity IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in retrograde transport, endosome to Golgi IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in retrograde transport, endosome to Golgi IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in retrograde transport, endosome to Golgi IPI
Inferred from Physical Interaction
more info
 PubMed 
involved_in retrograde transport, endosome to Golgi NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
is_active_in Golgi membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi membrane IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of Ric1-Rgp1 guanyl-nucleotide exchange factor complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Ric1-Rgp1 guanyl-nucleotide exchange factor complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
part_of guanyl-nucleotide exchange factor complex IDA
Inferred from Direct Assay
more info
 PubMed 
Preferred Names
Rgp1p
NP_010421.1
  • Subunit of a Golgi membrane exchange factor (Ric1p-Rgp1p); this complex catalyzes nucleotide exchange on Ypt6p

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    728259..730250
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180444.1 → NP_010421.1  TPA: Rgp1p

    See identical proteins and their annotated locations for NP_010421.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VSC0, P16664, Q03915
    UniProtKB/TrEMBL
    C7GIP2, G2WAN7, N1P893
    Conserved Domains (1) summary
    pfam08737
    Location:132 → 614
    Rgp1
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P16664.2

Gene LinkOut

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