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TRM1 tRNA (guanine26-N2)-dimethyltransferase [ Saccharomyces cerevisiae S288C ]

Gene ID: 851698, updated on 3-May-2025
Official Symbol
TRM1
Official Full Name
tRNA (guanine26-N2)-dimethyltransferase
Primary source
SGD:S000002527
Locus tag
YDR120C
See related
AllianceGenome:SGD:S000002527; FungiDB:YDR120C; VEuPathDB:YDR120C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables tRNA (guanine(26)-N2/guanine(27)-N2)-dimethyltransferase activity. Involved in tRNA methylation. Located in mitochondrion and nuclear inner membrane. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 68. Orthologous to human TRMT1 (tRNA methyltransferase 1). [provided by Alliance of Genome Resources, May 2025]
Orthologs
all
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See TRM1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (691549..693261, complement)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Vba4p Neighboring gene Cox26p Neighboring gene DNA polymerase epsilon noncatalytic subunit Neighboring gene serine/threonine protein kinase KIN1

Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Separate information required for nuclear and subnuclear localization: additional complexity in localizing an enzyme shared by mitochondria and nuclei. Rose AM, et al. Mol Cell Biol, 1992 Dec. PMID 1448094, Free PMC Article
  2. Isolation and characterization of the TRM1 locus, a gene essential for the N2,N2-dimethylguanosine modification of both mitochondrial and cytoplasmic tRNA in Saccharomyces cerevisiae. Ellis SR, et al. J Biol Chem, 1986 Jul 25. PMID 2426253
  3. Amino-terminal extension generated from an upstream AUG codon increases the efficiency of mitochondrial import of yeast N2,N2-dimethylguanosine-specific tRNA methyltransferases. Ellis SR, et al. Mol Cell Biol, 1989 Apr. PMID 2657400, Free PMC Article
  4. N2,N2-dimethylguanosine-specific tRNA methyltransferase contains both nuclear and mitochondrial targeting signals in Saccharomyces cerevisiae. Li JM, et al. J Cell Biol, 1989 Oct. PMID 2677019, Free PMC Article
  5. Amino-terminal extension generated from an upstream AUG codon is not required for mitochondrial import of yeast N2,N2-dimethylguanosine-specific tRNA methyltransferase. Ellis SR, et al. Proc Natl Acad Sci U S A, 1987 Aug. PMID 3299379, Free PMC Article

See all (82) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables tRNA (guanine(26)-N2)-dimethyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables tRNA (guanine(26)-N2/guanine(27)-N2)-dimethyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables tRNA (guanine(26)-N2/guanine(27)-N2)-dimethyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables tRNA (guanine) methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables tRNA binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within methylation IEA
Inferred from Electronic Annotation
more info
  
involved_in tRNA N2-guanine methylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tRNA methylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within tRNA modification IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within tRNA processing IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear envelope IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nuclear inner membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nuclear inner membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear inner membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
tRNA (guanine26-N2)-dimethyltransferase
NP_010405.3
  • tRNA methyltransferase; produces two isoforms based on alternative translational starts; localizes to the nucleus and mitochondrion, producing N2,N2-dimethylguanosine in tRNAs; involved in the methylation of guanosine and uridine ribonucleosides in mRNA; nuclear Trm1p is evenly distributed around the inner nuclear membrane in WT, but mislocalizes as puncta near ER-nucleus junctions in spindle pole body mutants; both Trm1p inner nuclear membrane targeting and maintenance depend upon the SPB

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    691549..693261 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180428.3 → NP_010405.3  TPA: tRNA (guanine26-N2)-dimethyltransferase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010405.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VSA6, P15565, Q9URQ7, Q9URQ8
    UniProtKB/TrEMBL
    N1PAD7
    Conserved Domains (1) summary
    TIGR00308
    Location:45 → 495
    TRM1; tRNA(guanine-26,N2-N2) methyltransferase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P15565.1

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