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FOB1 replication fork barrier binding protein FOB1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 851688, updated on 8-Jul-2018
Gene symbol
FOB1
Gene description
replication fork barrier binding protein FOB1
Primary source
SGD:S000002517
Locus tag
YDR110W
Gene type
protein coding
RNA name
replication fork barrier binding protein FOB1
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
HRM1
See FOB1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (676102..677802)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Trs85p Neighboring gene putative phosphotransferase Neighboring gene alanine transaminase ALT2 Neighboring gene securin

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Cell cycle - yeast, organism-specific biosystem (from KEGG)
    Cell cycle - yeast, organism-specific biosystemMitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps (G1 and G2 phases). G1, S, and G...
  • Cell cycle - yeast, conserved biosystem (from KEGG)
    Cell cycle - yeast, conserved biosystemMitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps (G1 and G2 phases). G1, S, and G...
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by GO

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
rDNA spacer replication fork barrier binding IDA
Inferred from Direct Assay
more info
PubMed 
rDNA spacer replication fork barrier binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
DNA recombination IEA
Inferred from Electronic Annotation
more info
 
DNA recombination IMP
Inferred from Mutant Phenotype
more info
PubMed 
DNA replication IEA
Inferred from Electronic Annotation
more info
 
chromatin organization IGI
Inferred from Genetic Interaction
more info
PubMed 
chromatin silencing at rDNA IDA
Inferred from Direct Assay
more info
PubMed 
chromatin silencing at rDNA IMP
Inferred from Mutant Phenotype
more info
PubMed 
chromosome segregation IGI
Inferred from Genetic Interaction
more info
PubMed 
dsDNA loop formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
extrachromosomal circular DNA accumulation involved in cell aging IMP
Inferred from Mutant Phenotype
more info
PubMed 
maintenance of rDNA IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of DNA replication IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of DNA recombination IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein localization to nucleolar rDNA repeats IMP
Inferred from Mutant Phenotype
more info
PubMed 
rDNA condensation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of cell aging IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of cell aging IMP
Inferred from Mutant Phenotype
more info
PubMed 
replication fork arrest at rDNA repeats IMP
Inferred from Mutant Phenotype
more info
PubMed 
replicative cell aging IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
nucleolus IEA
Inferred from Electronic Annotation
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 
rDNA heterochromatin IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
replication fork barrier binding protein FOB1
NP_010395.1
  • Nucleolar protein that binds the rDNA replication fork barrier site; required for replication fork blocking, recombinational hotspot activity, condensin recruitment to replication fork barrier (RFB), and rDNA repeat segregation; related to retroviral integrases

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    676102..677802
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180418.1NP_010395.1  TPA: replication fork barrier binding protein FOB1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010395.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O13329
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