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BMH2 14-3-3 family protein BMH2 [ Saccharomyces cerevisiae S288C ]

Gene ID: 851676, updated on 7-Jun-2026
Official Symbol
BMH2
Official Full Name
14-3-3 family protein BMH2
Primary source
SGD:S000002506
Locus tag
YDR099W
See related
AllianceGenome:SGD:S000002506; FungiDB:YDR099W; VEuPathDB:YDR099W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
SCD3
Summary
Enables DNA replication origin binding activity and phosphoserine residue binding activity. Involved in several processes, including DNA-templated DNA replication; chitin biosynthetic process; and intracellular signal transduction. Located in cytoplasm and nucleus. Orthologous to human YWHAE (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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See BMH2 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (653607..654428)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene tRNA-Gln Neighboring gene gag-pol fusion protein Neighboring gene gag protein Neighboring gene Tvp15p Neighboring gene putative hydrolase

Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Modulation of 14-3-3 protein interactions with target polypeptides by physical and metabolic effectors. Athwal GS, et al. Plant Cell Physiol, 2000 Apr. PMID 10845467
  2. The 14-3-3 proteins encoded by the BMH1 and BMH2 genes are essential in the yeast Saccharomyces cerevisiae and can be replaced by a plant homologue. van Heusden GP, et al. Eur J Biochem, 1995 Apr 1. PMID 7744048
  3. Transcriptomic and proteomic analysis of a 14-3-3 gene-deficient yeast. Ichimura T, et al. Biochemistry, 2004 May 25. PMID 15147199
  4. Regulation of transcription by Saccharomyces cerevisiae 14-3-3 proteins. Bruckmann A, et al. Biochem J, 2004 Sep 15. PMID 15142031, Free PMC Article
  5. The yeast 14-3-3 proteins BMH1 and BMH2 differentially regulate rapamycin-mediated transcription. Trembley MA, et al. Biosci Rep, 2014 Apr 1. PMID 27919033, Free PMC Article

See all (178) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Ca2+-triggered Atg11-Bmh1/2-Snf1 complex assembly initiates autophagy upon glucose starvation.
    Title: Ca2+-triggered Atg11-Bmh1/2-Snf1 complex assembly initiates autophagy upon glucose starvation.
  2. Lack of 14-3-3 proteins in Saccharomyces cerevisiae results in cell-to-cell heterogeneity in the expression of Pho4-regulated genes SPL2 and PHO84
    Title: Lack of 14-3-3 proteins in Saccharomyces cerevisiae results in cell-to-cell heterogeneity in the expression of Pho4-regulated genes SPL2 and PHO84.
  3. Both Bmh1 and Bmh2 associate with the promoters of at least some of these genes. BMH2, but not BMH1, attenuates the repression of genes involved in some functions required for ribosome biogenesis. BMH2 also attenuates the activation of genes sensitive to nitrogen catabolite repression.
    Title: The yeast 14-3-3 proteins BMH1 and BMH2 differentially regulate rapamycin-mediated transcription.
  4. Bmh2 is required for nuclear Gln3 localization and appears to function downstream of Ure2.
    Title: General Amino Acid Control and 14-3-3 Proteins Bmh1/2 Are Required for Nitrogen Catabolite Repression-Sensitive Regulation of Gln3 and Gat1 Localization.
  5. demonstrated the interaction of Rod1 with Hxt6 and showed that the localization of the Rod1-Hxt6 complex at the plasma membrane is affected by carbon source and is reduced upon overexpression of SNF1 and BMH2
    Title: Regulation of the Yeast Hxt6 Hexose Transporter by the Rod1 α-Arrestin, the Snf1 Protein Kinase, and the Bmh2 14-3-3 Protein.
  6. Data indicate that transcription activation is regulated negatively by two redundant 14-3-3 isoforms, Bmh1 and Bmh2.
    Title: Yeast 14-3-3 protein functions as a comodulator of transcription by inhibiting coactivator functions.
  7. Bmh1 and Bmh2 inhibit transcription by binding to Adr1 at promoters that contain a preinitiation complex, demonstrating that Bmh-mediated inhibition is not due to nuclear exclusion, inhibition of DNA binding, or RNA polymerase II (Pol II) recruitment.
    Title: 14-3-3 (Bmh) proteins regulate combinatorial transcription following RNA polymerase II recruitment by binding at Adr1-dependent promoters in Saccharomyces cerevisiae.
  8. Yeast BMH1 and BMH2 possess a distinctly variant C-terminal compared to human 14-3-3 zeta protein.
    Title: The C-terminal segment of yeast BMH proteins exhibits different structure compared to other 14-3-3 protein isoforms.
  9. BMH2 function as essential factors for the assembly and maintenance of the pre-replication complex during G1 phase.
    Title: 14-3-3 proteins function in the initiation and elongation steps of DNA replication in Saccharomyces cerevisiae.
  10. Nucleocytoplasmic shuttling of Pik1p involves phosphorylation and 14-3-3 proteins bind Pik1p in the cytoplasm.
    Title: Nucleocytoplasmic shuttling of the Golgi phosphatidylinositol 4-kinase Pik1 is regulated by 14-3-3 proteins and coordinates Golgi function with cell growth.
Submit: New GeneRIF Correction See all GeneRIFs (16)
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables DNA replication origin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA replication origin binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphoserine residue binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphoserine residue binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA damage checkpoint signaling IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA damage checkpoint signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in DNA replication initiation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in Ras protein signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in Ras protein signal transduction IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in ascospore formation IEA
Inferred from Electronic Annotation
more info
  
involved_in ascospore formation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in chitin biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in chitin biosynthetic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in intracellular protein localization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic cell cycle IPI
Inferred from Physical Interaction
more info
 PubMed 
involved_in negative regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of protein ubiquitination IPI
Inferred from Physical Interaction
more info
 PubMed 
involved_in pre-replicative complex assembly involved in nuclear cell cycle DNA replication IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in pseudohyphal growth IEA
Inferred from Electronic Annotation
more info
  
involved_in pseudohyphal growth IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in signal transduction involved in filamentous growth IEA
Inferred from Electronic Annotation
more info
  
involved_in signal transduction involved in filamentous growth IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus HDA PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane HDA PubMed 
Preferred Names
14-3-3 family protein BMH2
NP_010384.3
  • 14-3-3 protein, minor isoform; involved in post-transcriptional control of the proteome; binds to both proteins and to DNA, including replication origins; regulates multiple processes including exocytosis, vesicle transport, Ras/MAPK and rapamycin-sensitive signaling and meiotic commitment; protein abundance and relative distribution to the nucleus increase upon DNA replication stress; abundance relative to Bmh1p increases during sporulation; similar to several human 14-3-3 proteins

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    653607..654428
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180407.3 → NP_010384.3  14-3-3 family protein BMH2

    See identical proteins and their annotated locations for NP_010384.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A2TBP2, D6VS86, P34730, Q06HN5
    UniProtKB/TrEMBL
    A6ZY63, B3LGH5, B5VFZ8, C7GQJ5, C8Z516, G2WAK3, N1P4P6
    Conserved Domains (1) summary
    COG5040
    Location:1 → 273
    BMH1; 14-3-3 family protein [Signal transduction mechanisms]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P34730.3

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