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VPS41 Vps41p [ Saccharomyces cerevisiae S288C ]

Gene ID: 851653, updated on 4-Sep-2021

Summary

Gene symbol
VPS41
Gene description
Vps41p
Primary source
SGD:S000002487
Locus tag
YDR080W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
CVT8; FET2; SVL2; VAM2; VPL20
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Genomic context

See VPS41 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (604008..606986)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Pet100p Neighboring gene TFIIH complex subunit TFB5 Neighboring gene Pdc2p Neighboring gene Stn1p

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GO

Function Evidence Code Pubs
contributes_to phosphatidylinositol binding IDA
Inferred from Direct Assay
more info
PubMed 
enables small GTPase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in cellular response to starvation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cytoplasm to vacuole transport by the Cvt pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in endosomal vesicle fusion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
 
involved_in intracellular transport IEA
Inferred from Electronic Annotation
more info
 
involved_in macroautophagy IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in macroautophagy IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in piecemeal microautophagy of the nucleus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein targeting to vacuole IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein targeting to vacuole IEA
Inferred from Electronic Annotation
more info
 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
 
involved_in protein transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of SNARE complex assembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in vacuolar protein processing IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in vacuole fusion, non-autophagic IDA
Inferred from Direct Assay
more info
PubMed 
involved_in vacuole fusion, non-autophagic IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in vacuole organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in vesicle tethering IDA
Inferred from Direct Assay
more info
PubMed 
involved_in vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
 
involved_in vesicle-mediated transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of HOPS complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of HOPS complex IPI
Inferred from Physical Interaction
more info
PubMed 
located_in endosome HDA PubMed 
located_in fungal-type vacuole membrane HDA PubMed 
located_in fungal-type vacuole membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in late endosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in vacuole IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
Vps41p
NP_010365.3
  • Subunit of the HOPS endocytic tethering complex; vacuole membrane protein that functions as a Rab GTPase effector, interacting specifically with the GTP-bound conformation of Ypt7p, facilitating tethering, docking and promoting membrane fusion events at the late endosome and vacuole; required for both membrane and protein trafficking; Yck3p-mediated phosphorylation regulates the organization of vacuolar fusion sites

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    604008..606986
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180388.3NP_010365.3  TPA: Vps41p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010365.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P38959
    Conserved Domains (2) summary
    smart00299
    Location:753896
    CLH; Clathrin heavy chain repeat homology
    smart00320
    Location:145179
    WD40; WD40 repeats
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