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MAK21 RNA-binding ribosome biosynthesis protein MAK21 [ Saccharomyces cerevisiae S288C ]

Gene ID: 851632, updated on 14-Nov-2024

Summary

Official Symbol
MAK21
Official Full Name
RNA-binding ribosome biosynthesis protein MAK21
Primary source
SGD:S000002467
Locus tag
YDR060W
See related
AllianceGenome:SGD:S000002467; FungiDB:YDR060W; VEuPathDB:YDR060W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
NOC1
Summary
Enables mRNA binding activity. Involved in ribosomal large subunit assembly. Located in nucleolus. Part of Noc1p-Noc2p complex. Orthologous to human CEBPZ (CCAAT enhancer binding protein zeta). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

See MAK21 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (570649..573726)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene tRNA-Asp Neighboring gene E2 ubiquitin-conjugating protein UBC5 Neighboring gene uncharacterized protein Neighboring gene serine C-palmitoyltransferase LCB2

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables mRNA binding HDA PubMed 
Process Evidence Code Pubs
involved_in ribosomal large subunit assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in ribosomal large subunit biogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in ribosome biogenesis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of Noc1p-Noc2p complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
part_of preribosome, large subunit precursor IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
RNA-binding ribosome biosynthesis protein MAK21
NP_010345.3
  • Constituent of 66S pre-ribosomal particles; required for large (60S) ribosomal subunit biogenesis; acts as part of a Mak21p-Noc2p-Rrp5p module that associates with nascent pre-rRNA during transcription and has a role in bigenesis of the large ribosomal subunit; involved in nuclear export of pre-ribosomes; required for maintenance of dsRNA virus; homolog of human CAATT-binding protein

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    570649..573726
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180368.3NP_010345.3  TPA: RNA-binding ribosome biosynthesis protein MAK21 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010345.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VS46, Q12176
    UniProtKB/TrEMBL
    A6ZY25, C7GVS6, C8Z4X9
    Conserved Domains (1) summary
    COG5593
    Location:1731022
    COG5593; Nucleic-acid-binding protein possibly involved in ribosomal biogenesis [Translation, ribosomal structure and biogenesis]