U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

RPC11 DNA-directed RNA polymerase III core subunit RPC11 [ Saccharomyces cerevisiae S288C ]

Gene ID: 851615, updated on 11-Jun-2025
Official Symbol
RPC11
Official Full Name
DNA-directed RNA polymerase III core subunit RPC11
Primary source
SGD:S000002452
Locus tag
YDR045C
See related
AllianceGenome:SGD:S000002452; FungiDB:YDR045C; VEuPathDB:YDR045C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Contributes to DNA-directed RNA polymerase activity. Involved in tRNA transcription by RNA polymerase III and termination of RNA polymerase III transcription. Part of RNA polymerase III complex. Human ortholog(s) of this gene implicated in hypomyelinating leukodystrophy 21. Orthologous to human POLR3K (RNA polymerase III subunit K). [provided by Alliance of Genome Resources, Jun 2025]
Orthologs
NEW
Try the new Gene table
Try the new Transcript table
See RPC11 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (547978..548310, complement)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene transcriptional regulator NRG1 Neighboring gene coproporphyrinogen oxidase Neighboring gene amino acid transporter BAP3 Neighboring gene uroporphyrinogen decarboxylase HEM12

Genomic Sequence:
NC_001136.10
Products Interactant Other Gene Complex Source Pubs Description

Gene Ontology Provided by SGD

Function Evidence Code Pubs
contributes_to DNA-directed RNA polymerase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
contributes_to DNA-directed RNA polymerase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA-directed RNA polymerase activity IEA
Inferred from Electronic Annotation
more info
 
contributes_to DNA-directed RNA polymerase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
enables zinc ion binding RCA
inferred from Reviewed Computational Analysis
more info
PubMed 
Component Evidence Code Pubs
part_of DNA-directed RNA polymerase complex IEA
Inferred from Electronic Annotation
more info
 
part_of RNA polymerase III complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of RNA polymerase III complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of RNA polymerase III complex IEA
Inferred from Electronic Annotation
more info
 
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
DNA-directed RNA polymerase III core subunit RPC11
NP_010330.1
  • RNA polymerase III subunit C11; mediates pol III RNA cleavage activity and is important for termination of transcription; homologous to TFIIS

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    547978..548310 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180353.1NP_010330.1  TPA: DNA-directed RNA polymerase III core subunit RPC11 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010330.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VS33, Q04307, Q2VQW5
    UniProtKB/TrEMBL
    A6ZY12, B3LGM2, C7GTA4, C8Z4W5, G2WAF1, N1P824