RPC11 DNA-directed RNA polymerase III core subunit RPC11 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Gene symbol: RPC11
Gene description: DNA-directed RNA polymerase III core subunit RPC11
Primary source: SGD:S000002452
Locus tag: YDR045C
See related: AllianceGenome:SGD:S000002452
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Contributes to RNA polymerase III activity. Involved in tRNA transcription by RNA polymerase III and termination of RNA polymerase III transcription. Part of RNA polymerase III complex. Human ortholog(s) of this gene implicated in hypomyelinating leukodystrophy. Orthologous to human POLR3K (RNA polymerase III subunit K). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See RPC11 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 1

Sequence:: Chromosome: IV; NC_001136.10 (547978..548310, complement)

Chromosome IV - NC_001136.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Date indicate that RNA Polymerase III (RNAP III) subunits C53, C37, and C11 are required for pre-termination complex (PTC) formation.
Title: Mechanism of Transcription Termination by RNA Polymerase III Utilizes a Non-template Strand Sequence-Specific Signal Element.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by GO

Function	Evidence Code	Pubs
enables DNA-directed 5'-3' RNA polymerase activity	IEA Inferred from Electronic Annotation more info
contributes_to RNA polymerase III activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
contributes_to RNA polymerase III activity	IDA Inferred from Direct Assay more info	PubMed
contributes_to RNA polymerase III activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	RCA inferred from Reviewed Computational Analysis more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in tRNA 3'-end processing	IEA Inferred from Electronic Annotation more info
involved_in tRNA transcription by RNA polymerase III	IDA Inferred from Direct Assay more info	PubMed
involved_in tRNA transcription by RNA polymerase III	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in termination of RNA polymerase III transcription	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in termination of RNA polymerase III transcription	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of DNA-directed RNA polymerase complex	IEA Inferred from Electronic Annotation more info
part_of RNA polymerase III complex	IBA Inferred from Biological aspect of Ancestor more info	PubMed
part_of RNA polymerase III complex	IDA Inferred from Direct Assay more info	PubMed
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of transferase complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: DNA-directed RNA polymerase III core subunit RPC11

NP_010330.1

RNA polymerase III subunit C11; mediates pol III RNA cleavage activity and is important for termination of transcription; homologous to TFIIS

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001136.10 Reference assembly

Range

547978..548310 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001180353.1 → NP_010330.1 TPA: DNA-directed RNA polymerase III core subunit RPC11 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_010330.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q04307, Q2VQW5

UniProtKB/TrEMBL

A0A0L8VST0, A0A6C1DPR8, A0A6L0Y5S7, A0A8B8UNR8, A6ZY12, B3LGM2, C7GTA4, C8Z4W5, G2WAF1, J8Q6L4

Nucleotide		Protein
Heading	Accession and Version	Protein

Protein Accession	Links
Protein Accession	GenPept Link	UniProtKB Link
6CNB_I.1
6CNC_I.1
6CND_I.1
6CNF_I.1
6EU0_I.1
6EU1_I.1
6EU2_I.1
6EU3_I.1
6F40_I.1
6F41_I.1
6F42_I.1
6F44_I.1
6TUT_I.1
Q04307.1