RPC11 DNA-directed RNA polymerase III core subunit RPC11 [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: RPC11
Official Full Name: DNA-directed RNA polymerase III core subunit RPC11
Primary source: SGD:S000002452
Locus tag: YDR045C
See related: AllianceGenome:SGD:S000002452; FungiDB:YDR045C; VEuPathDB:YDR045C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Contributes to DNA-directed RNA polymerase activity. Involved in tRNA transcription by RNA polymerase III and termination of RNA polymerase III transcription. Part of RNA polymerase III complex. Human ortholog(s) of this gene implicated in hypomyelinating leukodystrophy 21. Orthologous to human POLR3K (RNA polymerase III subunit K). [provided by Alliance of Genome Resources, Jun 2025]
Orthologs: all
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Chromosome IV - NC_001136.10 Genomic Context describing neighboring genes

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
contributes_to DNA-directed RNA polymerase activity	IBA Inferred from Biological aspect of Ancestor more info
contributes_to DNA-directed RNA polymerase activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA-directed RNA polymerase activity	IEA Inferred from Electronic Annotation more info
contributes_to DNA-directed RNA polymerase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	RCA inferred from Reviewed Computational Analysis more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in tRNA transcription by RNA polymerase III	IDA Inferred from Direct Assay more info	PubMed
involved_in tRNA transcription by RNA polymerase III	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in termination of RNA polymerase III transcription	IBA Inferred from Biological aspect of Ancestor more info
involved_in termination of RNA polymerase III transcription	IEA Inferred from Electronic Annotation more info
involved_in termination of RNA polymerase III transcription	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of DNA-directed RNA polymerase complex	IEA Inferred from Electronic Annotation more info
part_of RNA polymerase III complex	IBA Inferred from Biological aspect of Ancestor more info
part_of RNA polymerase III complex	IDA Inferred from Direct Assay more info	PubMed
part_of RNA polymerase III complex	IEA Inferred from Electronic Annotation more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info